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1. (WO2017204446) METHOD FOR TESTING NK CELL ACTIVITY USING SYNERGISTIC ACTIVITY OF RECEPTOR, AND METHOD FOR DIAGNOSING DISEASE ASSOCIATED WITH NK CELL ACTIVITY USING SAME
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Pub. No.: WO/2017/204446 International Application No.: PCT/KR2017/002870
Publication Date: 30.11.2017 International Filing Date: 17.03.2017
IPC:
G01N 33/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
울산대학교 산학협력단 UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION [KR/KR]; 울산시 남구 대학로 93 93, Daehak-ro Nam-gu, Ulsan 44610, KR
재단법인 아산사회복지재단 THE ASAN FOUNDATION [KR/KR]; 서울시 송파구 올림픽로43길 88 88, Olympic-ro 43-gil Songpa-gu, Seoul 05505, KR
Inventors:
김헌식 KIM, Hun Sik; KR
명승재 MYUNG, Seung Jae; KR
김송철 KIM, Song Cheol; KR
Agent:
리앤목 특허법인 Y.P.LEE, MOCK & PARTNERS; 서울시 강남구 언주로 30길 13 대림아크로텔 12층 12F Daelim Acrotel, 13 Eonju-ro 30-gil Gangnam-gu, Seoul 06292, KR
Priority Data:
10-2016-006373524.05.2016KR
10-2017-003320716.03.2017KR
Title (EN) METHOD FOR TESTING NK CELL ACTIVITY USING SYNERGISTIC ACTIVITY OF RECEPTOR, AND METHOD FOR DIAGNOSING DISEASE ASSOCIATED WITH NK CELL ACTIVITY USING SAME
(FR) PROCÉDÉ D'ANALYSE DE L'ACTIVITÉ DE CELLULES TUEUSES NATURELLES À L'AIDE DE L'ACTIVITÉ SYNERGIQUE D'UN RÉCEPTEUR, ET PROCÉDÉ DE DIAGNOSTIC DE MALADIE ASSOCIÉE À L'ACTIVITÉ DES CELLULES TUEUSES NATURELLES UTILISANT LEDIT PROCÉDÉ D'ANALYSE
(KO) 수용체 시너지 활성을 이용한 NK 세포의 활성도 검사 방법 및 이를 이용한 NK 세포의 활성도가 관련된 질환의 진단 방법
Abstract:
(EN) The present invention relates to a method for testing NK cell activity and a composition for testing NK cell activity, the method for testing NK cell activity comprising the steps of: specifically stimulating at least two distinguishable factors in an NK cell in a sample; measuring the synergistic activation level of the NK cell; and comparing the synergistic activation level of the NK cell against that of a normal NK cell. In addition, the present invention relates to a kit for diagnosing a disease associated with the synergistic activity of a NK cell, the kit comprising the composition.
(FR) La présente invention concerne un procédé permettant d'analyser l'activité de cellules tueuses naturelles et une composition permettant d'analyser l'activité des cellules tueuses naturelles, ledit procédé permettant d'analyser l'activité des cellules tueuses naturelles comprenant les étapes consistant à : stimuler spécifiquement au moins deux facteurs distincts dans une cellule tueuse naturelle dans un échantillon; mesurer le niveau d'activation synergique de la cellule tueuse naturelle; et comparer le niveau d'activation synergique de la cellule tueuse naturelle avec celui d'une cellule tueuse naturelle normale. De plus, la présente invention concerne un kit permettant de diagnostiquer une maladie associée à l'activité synergique d'une cellule tueuse naturelle, ledit kit comprenant ladite composition.
(KO) 본 발명은 시료 내의 NK 세포 상에 구별되는 두 개 이상의 인자를 특이적으로 자극하는 단계; 상기 NK 세포의 시너지 활성화 정도를 측정하는 단계; 및 정상 NK 세포 대비 상기 NK 세포의 시너지 활성화 정도를 비교하는 단계를 포함하는 NK 세포의 활성도 검사 방법 및 NK 세포의 활성도 검사용 조성물에 관한 것이다. 또한, 본 발명은 상기 조성물을 포함하는 NK 세포의 시너지 활성과 관련된 질환의 진단용 키트에 관한 것이다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)