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1. (WO2017204349) METHODS AND ASSAYS FOR ESTIMATING ACID-FAST BACTERIA VIABILITY, AND KITS THEREFOR
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Pub. No.: WO/2017/204349 International Application No.: PCT/JP2017/019794
Publication Date: 30.11.2017 International Filing Date: 26.05.2017
IPC:
C12Q 1/24 (2006.01) ,C07K 16/12 (2006.01) ,G01N 33/569 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
24
Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact micro-organism
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12
against material from bacteria
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants:
OTSUKA PHARMACEUTICAL CO., LTD. [JP/JP]; 2-9, Kanda Tsukasa-machi, Chiyoda-ku, Tokyo 1018535, JP
Inventors:
KAWASAKI, Masanori; JP
LIU, Yongge; US
KATSURAGI, Kiyonori; JP
Agent:
SAMEJIMA, Mutsumi; JP
MATSUTANI, Michiko; JP
Priority Data:
62/34245827.05.2016US
Title (EN) METHODS AND ASSAYS FOR ESTIMATING ACID-FAST BACTERIA VIABILITY, AND KITS THEREFOR
(FR) PROCÉDÉS ET ESSAIS D’ESTIMATION DE LA VIABILITÉ DE BACTÉRIES RÉSISTANTES AUX ACIDES, ET TROUSSES ASSOCIÉES
Abstract:
(EN) The present invention relates to assays and methods for calculating, estimating, or determining, the amount of viable acid-fast bacilli in a sample based on the result of the detection of lipoarabinomannan (LAM). The present disclosure further relates to the detection of LAM of acid-fast bacilli using an antibody, and calculating, estimating, or determining, the amount of viable acid-fast bacilli in a sample based on the result of the detection of LAM. These assays and methods may be used for the monitoring of treatments for tuberculosis, and for the development and testing of new treatments.
(FR) La présente invention concerne des essais et des procédés de calcul, d’estimation, ou de détermination, de la quantité de bacilles viables résistants aux acides dans un échantillon sur la base du résultat de la détection de lipoarabinomannane (LAM). La présente description concerne en outre la détection de LAM de bacilles résistants aux acides en utilisant un anticorps, et le calcul, l’estimation, ou la détermination, de la quantité des bacilles viables résistants aux acides dans un échantillon sur la base du résultat de la détection de LAM. Ces essais et ces procédés peuvent être utilisés pour la surveillance de traitements contre la tuberculose, et pour le développement et le test de nouveaux traitements.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)