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1. (WO2017204277) ANTI-TGF-beta3 ANTIBODY AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/204277    International Application No.:    PCT/JP2017/019457
Publication Date: 30.11.2017 International Filing Date: 25.05.2017
IPC:
C07K 16/22 (2006.01), A61K 39/395 (2006.01), A61P 5/14 (2006.01), A61P 19/02 (2006.01), A61P 21/04 (2006.01), A61P 25/00 (2006.01), A61P 29/00 (2006.01), A61P 31/00 (2006.01), A61P 37/02 (2006.01), A61P 37/06 (2006.01), C12N 15/09 (2006.01)
Applicants: THE UNIVERSITY OF TOKYO [JP/JP]; 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654 (JP).
CHUGAI SEIYAKU KABUSHIKI KAISHA [JP/JP]; 5-1, Ukima 5-chome, Kita-ku, Tokyo 1158543 (JP)
Inventors: FUJIO, Keishi; (JP).
OKAMURA, Tomohisa; (JP).
YAMAMOTO, Kazuhiko; (JP).
INOUE, Mariko; (JP).
KOMAI, Toshihiko; (JP).
BAN, Nobuhiro; (JP).
NONAKA, Tatsuya; (JP).
ISHII, Shinya; (JP).
MURATA, Hiroko; (JP)
Agent: HARUNA, Masao; (JP).
SHIMIZU, Hatsushi; (JP).
YAMAGUCHI, Hirotaka; (JP).
OSAKABE, Suguru; (JP).
INOUE, Ryuichi; (JP).
SATO, Toshimitsu; (JP).
SHIMMI, Hirokazu; (JP).
KOBAYASHI, Tomohiko; (JP).
KODERA, Hideki; (JP).
OHZEKI, Masato; (JP).
IGARASHI, Yoshihiro; (JP).
KAWAMOTO, Kazuya; (JP)
Priority Data:
2016-106099 27.05.2016 JP
Title (EN) ANTI-TGF-beta3 ANTIBODY AND USE THEREOF
(FR) ANTICORPS ANTI-TGF-Β3 ET UTILISATION ASSOCIÉE
(JA) 抗TGF-beta3抗体およびその使用
Abstract: front page image
(EN)The present invention provides an anti-TGF-beta3 antibody and a method of using the antibody. The anti-TGF-beta3 antibody according to the present invention has a binding activity to TGF-beta3 but does not have a neutralizing activity to TGF-beta3, and is useful as an inhibitor for the activation of B-cells and as a therapeutic agent for autoimmune diseases.
(FR)La présente invention concerne un anticorps anti-TGF-β3 et une méthode d'utilisation de l'anticorps. L'anticorps anti-TGF-β3 selon la présente invention présente une activité de liaison au TGF-β3 mais n'a pas d'activité neutralisante vis-à-vis du TGF-bêta3, et est utile en tant qu'inhibiteur pour l'activation de lymphocytes B et en tant qu'agent thérapeutique pour des maladies auto-immunes.
(JA)本発明は、抗TGF-beta3抗体および同抗体を使用する方法を提供する。本発明の抗TGF-beta3抗体は、TGF-beta3に対する結合活性は有するがTGF-beta3に対する中和活性は有さず、B細胞活性化の抑制剤および自己免疫疾患の治療剤として有用である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)