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1. (WO2017203520) METHODS OF USING PULMONARY CELLS FOR TRANSPLANTATION AND INDUCTION OF TOLERANCE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/203520    International Application No.:    PCT/IL2017/050569
Publication Date: 30.11.2017 International Filing Date: 22.05.2017
IPC:
A61K 35/42 (2015.01), A61P 11/00 (2006.01)
Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD. [IL/IL]; at the Weizmann Institute of Science P.O. Box 95 7610002 Rehovot (IL)
Inventors: REISNER, Yair; (IL).
HILLEL-KARNIEL, Carmit; (IL).
ROSEN, Chava; (IL).
BACHAR-LUSTIG, Esther; (IL).
SHEZEN, Elias; (IL)
Agent: EHRLICH, Gal; (IL).
EHRLICH, Gal; (IL).
WATERMAN, Hadassa; (IL).
MELNICK, Geoffrey, L.; (IL)
Priority Data:
62/339,887 22.05.2016 US
62/353,709 23.06.2016 US
Title (EN) METHODS OF USING PULMONARY CELLS FOR TRANSPLANTATION AND INDUCTION OF TOLERANCE
(FR) MÉTHODES D'UTILISATION DE CELLULES PULMONAIRES POUR TRANSPLANTATION ET INDUCTION DE TOLÉRANCE
Abstract: front page image
(EN)A method of treating a pulmonary disorder or injury in a subject in need thereof is disclosed. The method comprising administering to the subject non-syngeneic pulmonary tissue cells in suspension comprising an effective amount of hematopoietic precursor cells (HPCs) or supplemented with HPCs, wherein the effective amount is a sufficient amount to achieve tolerance to the pulmonary tissue cells in the absence of chronic immunosuppressive regimen. A method of inducing donor specific tolerance in a subject in need of a pulmonary cell or tissue transplantation is also disclosed.
(FR)L' invention concerne une méthode de traitement de trouble ou lésion pulmonaire chez un sujet nécessitant un traitement. La méthode consiste à administrer au sujet des cellules du tissu pulmonaire non syngéniques en suspension comprenant une quantité efficace de cellules précurseurs hématopoïétiques (HPC) ou complémentées par des HPC, la quantité efficace étant une quantité suffisante pour obtenir une tolérance aux cellules du tissu pulmonaire en l'absence de régime immunosuppresseur chronique. L'invention porte également sur une méthode visant à induire une tolérance spécifique au donneur chez un sujet nécessitant une transplantation de cellules ou de tissu pulmonaires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)
Licensing availability request The applicant has requested the International Bureau to indicate the availability for licensing purposes of the invention(s) claimed in this international application