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1. (WO2017202886) METHODS FOR DETECTING, ASSESSING SEVERITY AND TREATING MULTIPLE SCLEROSIS
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Pub. No.:
WO/2017/202886
International Application No.:
PCT/EP2017/062500
Publication Date:
30.11.2017
International Filing Date:
24.05.2017
IPC:
G01N 33/68
(2006.01)
G
PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
[FR/FR]; 101, rue de Tolbiac 75013 Paris (FR).
UNIVERSITÉ DE NANTES
[FR/FR]; 1, quai de Tourville 44000 Nantes (FR).
CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
[FR/FR]; 5 allée de l'Ile Gloriette 44000 Nantes (FR)
Inventors:
GUILLONNEAU, Carole
; (FR).
LAPLAUD, David
; (FR).
BEZIE, Séverine
; (FR).
NICOL, Bryan
; (FR)
Agent:
COLLIN, Matthieu
; (FR)
Priority Data:
16305606.2
25.05.2016
EP
Title
(EN)
METHODS FOR DETECTING, ASSESSING SEVERITY AND TREATING MULTIPLE SCLEROSIS
(FR)
PROCÉDÉS DE DÉTECTION, D'ÉVALUATION DE LA GRAVITÉ ET DE TRAITEMENT DE LA SCLÉROSE EN PLAQUES
Abstract:
(EN)
The present invention relates to methods for detecting, assessing severity and treating multiple sclerosis. The inventors showed an impairment of the function of CD8+ Treg cells in MS patients and they demonstrated here that several criteria correlated with the disease severity i.e. the percentage of CD8
+
CD45RC
int
CD161
low
Valpha7
-
T cells in the blood, the secretion of IFNg and IL10 and the suppressive activity of the CD8
+
CD45RC
int
CD161
low
Valpha7
-
T cells. In particular, the present invention relates to a method for determining whether a subject has or is at risk of having multiple sclerosis comprising i) determining the percentage of CD8
+
CD45RC
int
CD161
low
Valpha7
-
T cells in a biological sample obtained from the subject, ii) comparing the percentage determined at step i) with a predetermined reference value and iii) detecting differential in the percentage determined at step i) with the predetermined reference value indicates that the subject has or is at risk of having multiple sclerosis.
(FR)
La présente invention concerne des procédés de détection, d'évaluation de la gravité et de traitement de la sclérose en plaques. Les inventeurs ont montré une défaillance de la fonction des lymphocytes T régulateurs (Treg) CD8+ chez les patients atteints de sclérose en plaques et ont démontré ici que plusieurs critères étaient corrélés avec la sévérité de la maladie, à savoir le pourcentage de lymphocytes T CD8
+
CD45RC
int
CD161
low
Valpha7
-
dans le sang, la sécrétion d'IFNg et d'IL10 et l'activité suppressive des lymphocytes T CD8
+
CD45RC
int
CD161
low
Valpha7
-
. En particulier, la présente invention concerne un procédé permettant de déterminer si un patient présente ou risque de présenter une sclérose en plaques, consistant à i) déterminer le pourcentage de lymphocytes T CD8
+
CD45RC
int
CD161
low
Valpha7
-
dans un échantillon biologique obtenu chez le patient, ii) comparer le pourcentage déterminé à l'étape i) avec une valeur de référence prédéterminée et iii) détecter une différence entre le pourcentage déterminé à l'étape i) et la valeur de référence prédéterminée afin d'indiquer si le patient présente ou risque de présenter une sclérose en plaques.
Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language:
English (
EN
)
Filing Language:
English (
EN
)