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1. (WO2017202886) METHODS FOR DETECTING, ASSESSING SEVERITY AND TREATING MULTIPLE SCLEROSIS

Pub. No.:    WO/2017/202886    International Application No.:    PCT/EP2017/062500
Publication Date: Fri Dec 01 00:59:59 CET 2017 International Filing Date: Thu May 25 01:59:59 CEST 2017
IPC: G01N 33/68
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
UNIVERSITÉ DE NANTES
CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
Inventors: GUILLONNEAU, Carole
LAPLAUD, David
BEZIE, Séverine
NICOL, Bryan
Title: METHODS FOR DETECTING, ASSESSING SEVERITY AND TREATING MULTIPLE SCLEROSIS
Abstract:
The present invention relates to methods for detecting, assessing severity and treating multiple sclerosis. The inventors showed an impairment of the function of CD8+ Treg cells in MS patients and they demonstrated here that several criteria correlated with the disease severity i.e. the percentage of CD8+CD45RCintCD161lowValpha7- T cells in the blood, the secretion of IFNg and IL10 and the suppressive activity of the CD8+CD45RCintCD161lowValpha7- T cells. In particular, the present invention relates to a method for determining whether a subject has or is at risk of having multiple sclerosis comprising i) determining the percentage of CD8+CD45RCintCD161lowValpha7- T cells in a biological sample obtained from the subject, ii) comparing the percentage determined at step i) with a predetermined reference value and iii) detecting differential in the percentage determined at step i) with the predetermined reference value indicates that the subject has or is at risk of having multiple sclerosis.