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1. (WO2017202816) 3-OXO-2,6-DIPHENYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/202816    International Application No.:    PCT/EP2017/062355
Publication Date: 30.11.2017 International Filing Date: 23.05.2017
IPC:
C07D 237/16 (2006.01), C07D 237/20 (2006.01), C07D 403/12 (2006.01), C07D 405/12 (2006.01), A61P 35/00 (2006.01), A61K 31/501 (2006.01)
Applicants: BAYER PHARMA AKTIENGESELLSCHAFT [DE/DE]; Müllerstraße 178 13353 Berlin (DE).
DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ) [DE/DE]; Im Neuenheimer Feld 280 69120 Heidelberg (DE)
Inventors: SCHMEES, Norbert; (DE).
GUTCHER, Ilona; (DE).
IRLBACHER, Horst; (DE).
BADER, Benjamin; (DE).
ZHAO, Na; (CN).
PLATTEN, Michael; (DE)
Agent: BIP PATENTS; Alfred-Nobel-Str. 10 40789 Monheim am Rhein (DE)
Priority Data:
PCT/CN2016/083308 25.05.2016 CN
PCT/CN2017/074408 22.02.2017 CN
Title (EN) 3-OXO-2,6-DIPHENYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES
(FR) 3-OXO-2,6-DIPHÉNYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES
Abstract: front page image
(EN)The present invention covers 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
(FR)La présente invention concerne des composés 3-oxo-2,6-diphényl-2,3-dihydropyridazine-4-carboxamide de formule générale (I), dans laquelle R1, R2, R3, R4, R5 et R6 sont tels que définis dans la description, des procédés de préparation desdits composés, des composés intermédiaires utilisés pour préparer lesdits composés, des compositions et des combinaisons pharmaceutiques comprenant lesdits composés, et l'utilisation desdits composés pour fabriquer des compositions pharmaceutiques pour le traitement ou la prophylaxie de maladies, en particulier le cancer ou les maladies avec dérèglement des réponses immunitaires ou d'autres troubles associés aux signaux AHR aberrants, en monothérapie ou en association avec d'autres principes actifs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)