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1. (WO2017202343) 5-MEMBERED HETEROCYCLE FUSED WITH [3,4-D]PYRIDAZINONE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
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Pub. No.:    WO/2017/202343    International Application No.:    PCT/CN2017/085765
Publication Date: 30.11.2017 International Filing Date: 24.05.2017
IPC:
C07D 487/04 (2006.01), A61K 31/5025 (2006.01), A61K 31/5377 (2006.01), A61K 31/541 (2006.01)
Applicants: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN/CN]; 555 Zu Chong Zhi Road, Zhang Jiang, Pudong Shanghai 201203 (CN)
Inventors: JIANG, Hualiang; (CN).
LIU, Hong; (CN).
GENG, Meiyu; (CN).
ZHENG, Mingyue; (CN).
AI, Jing; (CN).
WANG, Yulan; (CN).
WU, Xiaowei; (CN).
LI, Shuangjie; (CN).
PENG, Xia; (CN).
LI, Chunpu; (CN).
CHEN, Kaixian; (CN).
WANG, Bao; (CN)
Agent: XU & PARTNERS, LLC.; Room No.106, Building No.1, Universal High-Tech Plaza, 958 Zhen Bei Road, Putuo District Shanghai 200333 (CN)
Priority Data:
201610353035.2 24.05.2016 CN
201710060243.8 24.01.2017 CN
Title (EN) 5-MEMBERED HETEROCYCLE FUSED WITH [3,4-D]PYRIDAZINONE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
(FR) HÉTÉROCYCLE À 5 ÉLÉMENTS FUSIONNÉ AVEC [3,4-D]PYRIDAZINONE, SON PROCÉDÉ DE FABRICATION, COMPOSITION PHARMACEUTIQUE ET SON APPLICATION
(ZH) 五元杂环并[3,4-d]哒嗪酮类化合物、其制备方法、药物组合物及其应用
Abstract: front page image
(EN)The present invention provides a compound comprising a 5-membered heterocycle fused with a pyridazinone, wherein the compound is used as an FGFR kinase inhibitor, and a manufacturing method and application thereof. The invention specifically provides a compound as represented by formula (I). Various radicals are as defined in the specification. The compound provided by the invention effectively inhibits an activity of an FGFR kinase, and can be used to manufacture a pharmaceutical product for treating a disease related to the activity of the FGFR kinase.
(FR)La présente invention concerne un composé comprenant un hétérocycle à 5 éléments fusionné avec de la pyridazinone, le composé étant utilisé en tant qu'inhibiteur de kinase FGFR, et un procédé de fabrication et son application. L'invention concerne plus précisément un composé représenté par la formule (I). Divers radicaux sont tels que définis dans la description. Le composé de l'invention inhibe efficacement l'activité d'une kinase FGFR et peut être utilisé pour fabriquer un produit pharmaceutique destiné à traiter une maladie liée à l'activité de la kinase FGFR.
(ZH)本发明提供了一种作为FGFR激酶抑制剂的五元杂环并哒嗪酮类化合物及其制备和应用,具体地,本发明提供了一种如下式(I)所示的化合物;其中,各基团的定义如说明书中所述。本发明的化合物具有很好的FGFR激酶抑制活性,可以用于制备一系列治疗FGFR激酶活性相关的疾病的药物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)