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1. (WO2017202291) THIOPHENE, MANUFACTURING METHOD THEREOF, AND PHARMACEUTICAL APPLICATION OF SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/202291    International Application No.:    PCT/CN2017/085458
Publication Date: 30.11.2017 International Filing Date: 23.05.2017
IPC:
C07D 409/04 (2006.01), C07D 405/04 (2006.01), C07D 495/04 (2006.01), C07D 409/14 (2006.01), A61P 19/06 (2006.01)
Applicants: CSTONE PHARMACEUTICALS (SHANGHAI) CO., LTD. [CN/CN]; Room 211-20, Building 1, 38 Debao Road, Pilot Free Trade Zone Shanghai 200000 (CN).
CSTONE PHARMACEUTICAL (SUZHOU) CO., LTD. [CN/CN]; 218 Xinghu St, Building A1 E168, Suzhou Industrial Park Jiangsu 215123 (CN).
CSTONE PHARMACEUTICALS; P.O. Box 31119, Grand Pavilion, Hibiscus Way, 802 West Bay Road, KY1-1205 Grand Cayman (KY)
Inventors: WANG, Jianfei; (CN).
ZHANG, Yang; (CN).
ZHU, Wenyuan; (CN).
CHEN, Shuhui; (CN)
Agent: SHANGHAI BESHINING LAW OFFICE; 21st Floor SFECO Mansion 681 Xiaomuqiao Road Shanghai 200032 (CN)
Priority Data:
201610343321.0 23.05.2016 CN
Title (EN) THIOPHENE, MANUFACTURING METHOD THEREOF, AND PHARMACEUTICAL APPLICATION OF SAME
(FR) THIOPHÈNE, SON PROCÉDÉ DE FABRICATION, ET APPLICATION PHARMACEUTIQUE CORRESPONDANTE
(ZH) 噻吩化合物及其合成方法和其在医药上的应用
Abstract: front page image
(EN)The present invention discloses a thiophene used as a uric acid transporter (URAT1) inhibitor and application of the thiophene in preparing a pharmaceutical product for treating a disease related to abnormal uric acid levels, specifically in preparing a pharmaceutical product for treating hyperuricemia and gouty arthritis. The invention specifically relates to a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof.
(FR)La présente invention concerne un thiophène utilisé comme inhibiteur du transporteur de l'acide urique (URAT1) et l'application du thiophène dans la préparation d'un produit pharmaceutique destiné au traitement d'une maladie liée aux niveaux anormaux d'acide urique, particulièrement dans la préparation d'un produit pharmaceutique destiné au traitement de l'hyperuricémie et de l'arthrite de la goutte. L'invention concerne particulièrement un composé tel que représenté par la formule (I) ou son sel de qualité pharmaceutique.
(ZH)本发明公开了一类作为尿酸盐转运体(URAT1)抑制剂的噻吩化合物及其在制备治疗尿酸水平异常病症药物中的应用,特别是在制备治疗高尿酸血症和痛风性关节炎药物上的应用。具体涉及式(Ⅰ)所示化合物或其药学上可接受的盐。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)