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1. (WO2017202274) NICOTINYL ALCOHOL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF
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Pub. No.: WO/2017/202274 International Application No.: PCT/CN2017/085418
Publication Date: 30.11.2017 International Filing Date: 23.05.2017
IPC:
C07D 405/14 (2006.01) ,C07D 207/16 (2006.01) ,A61K 31/40 (2006.01) ,A61K 31/44 (2006.01) ,A61P 35/00 (2006.01) ,A61P 31/04 (2006.01) ,A61P 31/12 (2006.01) ,A61P 37/02 (2006.01)
Applicants: INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES[CN/CN]; ZHANG Xubin No.A2, Nan Wei Road, Xicheng District Beijing 100050, CN
Inventors: FENG, Zhiqiang; CN
CHEN, Xiaoguang; CN
YANG, Yang; CN
ZHENG, Yi; CN
LAI, Fangfang; CN
JI, Ming; CN
ZHOU, Chuan; CN
ZHANG, Lijing; CN
WANG, Ke; CN
XUE, Nina; CN
LI, Ling; CN
Priority Data:
201610343960.723.05.2016CN
Title (EN) NICOTINYL ALCOHOL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF
(FR) DÉRIVÉ D'ÉTHER D'ALCOOL NICOTINYLIQUE, PROCÉDÉ DE PRÉPARATION ASSOCIÉ, COMPOSITION PHARMACEUTIQUE ET SES UTILISATIONS
(ZH) 烟醇醚类衍生物、及其制法和药物组合物与用途
Abstract: front page image
(EN) Disclosed are a nicotinyl alcohol ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the present invention relates to nicotinyl alcohol ether derivative represented by formula (I), a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.
(FR) L'invention concerne un dérivé d'éther d'alcool nicotinylique, procédé de préparation associé, et une composition pharmaceutique et ses utilisations. Plus précisément, la présente invention porte sur un dérivé d'éther d'alcool nicotinylique représenté par la formule (I), son sel de qualité pharmaceutique, son stéréoisomère et un procédé de préparation associé, une composition pharmaceutique comportant le ou les composés, et des utilisations des composés dans le cadre du traitement de maladies associées aux canaux de signalisation PD -1/PD-L1, tels que les cancers, les maladies infectieuses et les maladies auto-immunes.
(ZH) 公开了一类烟醇醚类衍生物、及其制法和药物组合物与用途。具体而言,涉及通式(I)所示的烟醇醚类衍生物,其可药用盐,其立体异构体及其制备方法,含有一个或多个这化合物的组合物,和该类化合物在治疗与PD-1/PD-L1信号通路有关的疾病如癌症、感染性疾病、自身免疫性疾病方面的用途。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)