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1. (WO2017202206) SUBSTITUTED QUINOLINE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/202206    International Application No.:    PCT/CN2017/083878
Publication Date: 30.11.2017 International Filing Date: 11.05.2017
IPC:
C07D 215/40 (2006.01), C07B 59/00 (2006.01), A61K 31/496 (2006.01), A61P 25/24 (2006.01), A61P 25/22 (2006.01), A61P 25/28 (2006.01), A61P 25/14 (2006.01), A61P 25/18 (2006.01), A61P 9/10 (2006.01), A61P 3/04 (2006.01)
Applicants: SHENZHEN TARGETRX, INC. [CN/CN]; Room 301, Building A1 Kexing Science Park, No.15 of Keyuan Road, Nanshan District Shenzhen, Guangdong 518057 (CN)
Inventors: WANG, Yihan; (CN).
LI, Huanyin; (CN)
Priority Data:
201610362199.1 27.05.2016 CN
Title (EN) SUBSTITUTED QUINOLINE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF
(FR) COMPOSÉ QUINOLÉINE SUBSTITUÉ ET COMPOSITION PHARMACEUTIQUE CORRESPONDANTE
(ZH) 一种取代的喹啉化合物及其药物组合物
Abstract: front page image
(EN)The present invention discloses a substituted quinoline compound as shown in formula (I), a pharmaceutical composition comprising said compound or a polymorph, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, an isotopic variant, a hydrate, or a solvate of same, and an application thereof. The substituted quinoline compound disclosed in the present invention and the pharmaceutical composition comprising said compound can act as a 5-HT6 receptor antagonist, having good pharmacokinetic parameter characteristics, and being able to be used for preparing medicine for the treatment of Alzheimer's disease.
(FR)La présente invention concerne un composé quinoléine substitué tel que présenté dans la formule (I), une composition pharmaceutique comportant ledit composé ou son polymorphe, son sel de qualité pharmaceutique, son promédicament, son stéréo-isomère, son variant isotopique, son hydrate ou son solvate, et son application. Le composé quinoléine substitué selon la présente invention et la composition pharmaceutique comportant ledit composé peuvent agir comme un antagoniste du récepteur 5-HT6, possèdent de bonnes caractéristiques de paramètres pharmacocinétiques et peuvent entrer dans la préparation d'un médicament destiné au traitement de la maladie d'Alzheimer.
(ZH)本发明公开了如式(I)所示的取代的喹啉化合物以及含有该化合物、或其多晶型、药学上可接受的盐、前药、立体异构体、同位素变体、水合物或溶剂合物的药物组合物及其用途。本发明公开的喹啉化合物及包含该化合物的组合物可作为5-HT6受体拮抗剂,同时具有更好的药代动力学参数特性,能够用于制备治疗阿尔茨海默症的药物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)