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1. (WO2017202193) APPLICATIONS OF RECOMBINANT KETOREDUCTASE IN PREPARATION OF (R)-3-QUINUCLIDINOL
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/202193    International Application No.:    PCT/CN2017/083434
Publication Date: 30.11.2017 International Filing Date: 08.05.2017
IPC:
C12N 9/06 (2006.01), C12P 17/18 (2006.01)
Applicants: SYNCOZYMES (SHANGHAI) CO., LTD. [CN/CN]; Bldg 1-101, No. 1199 Landian Road, Pudong New District Shanghai 201318 (CN)
Inventors: ZHU, Wei; (CN).
GAO, Xinxing; (CN).
WU, Hui; (CN).
WANG, Bo; (CN)
Agent: SUNHOLD LAW FIRM; 16F, Haoran High-tech Building, SJTU, No. 1954 Huashan Road Shanghai 200030 (CN)
Priority Data:
201610357377.1 26.05.2016 CN
Title (EN) APPLICATIONS OF RECOMBINANT KETOREDUCTASE IN PREPARATION OF (R)-3-QUINUCLIDINOL
(FR) APPLICATIONS D'UNE CÉTORÉDUCTASE RECOMBINANTE DANS LA PRÉPARATION DE (R)-3-QUINUCLIDINOL
(ZH) 重组酮还原酶在制备(R)-3-奎宁醇中的应用
Abstract: front page image
(EN)Provided are applications of a recombinant ketoreductase in the preparation of (R)-3-quinuclidinol. The amino acid sequence of the recombinant ketoreductase is shown by any one of SEQ ID No.2, 4, 6, 8 and 10. A product is obtained in a reaction carried out by mixing the recombinant ketoreductase, 3-quinuclidone or 3-quinuclidinone hydrochloride, a cofactor, a buffer, a recombinant glucose dehydrogenase and glucose in a proportion.
(FR)La présente invention concerne des applications d'une cétoréductase recombinante dans la préparation de (R)-3-quinuclidinol. La séquence d'acides aminés de la cétoréductase recombinante est représentée par l'une quelconque des SEQ ID no : 2, 4, 6, 8 et 10. Un produit est obtenu dans une réaction réalisée en mélangeant la cétoréductase recombinante, de la 3-quinuclidone ou du chlorhydrate de 3-quinuclidinone, un cofacteur, un tampon, une glucose déshydrogénase recombinante et du glucose en une certaine proportion.
(ZH)提供一种重组酮还原酶在制备(R)-3-奎宁醇中的应用,其中重组酮还原酶的氨基酸序列如SEQ ID No.2、4、6、8、10中任一项所示,将重组酮还原酶、3-奎宁环酮或3-奎宁环酮盐酸盐、辅因子、缓冲液、重组葡萄糖脱氢酶、葡萄糖按一定比例混合反应得到产物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)