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1. (WO2017202193) APPLICATIONS OF RECOMBINANT KETOREDUCTASE IN PREPARATION OF (R)-3-QUINUCLIDINOL
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Pub. No.: WO/2017/202193 International Application No.: PCT/CN2017/083434
Publication Date: 30.11.2017 International Filing Date: 08.05.2017
IPC:
C12N 9/06 (2006.01) ,C12P 17/18 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02
Oxidoreductases (1.), e.g. luciferase
06
acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17
Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
18
containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
Applicants:
尚科生物医药(上海)有限公司 SYNCOZYMES (SHANGHAI) CO., LTD. [CN/CN]; 中国上海市 浦东新区蓝靛路1199号1号楼101 Bldg 1-101, No. 1199 Landian Road, Pudong New District Shanghai 201318, CN
Inventors:
竺伟 ZHU, Wei; CN
高新星 GAO, Xinxing; CN
吴会 WU, Hui; CN
王波 WANG, Bo; CN
Agent:
上海申浩律师事务所 SUNHOLD LAW FIRM; 中国上海市 华山路1954号浩然高科技大厦16层 16F, Haoran High-tech Building, SJTU, No. 1954 Huashan Road Shanghai 200030, CN
Priority Data:
201610357377.126.05.2016CN
Title (EN) APPLICATIONS OF RECOMBINANT KETOREDUCTASE IN PREPARATION OF (R)-3-QUINUCLIDINOL
(FR) APPLICATIONS D'UNE CÉTORÉDUCTASE RECOMBINANTE DANS LA PRÉPARATION DE (R)-3-QUINUCLIDINOL
(ZH) 重组酮还原酶在制备(R)-3-奎宁醇中的应用
Abstract:
(EN) Provided are applications of a recombinant ketoreductase in the preparation of (R)-3-quinuclidinol. The amino acid sequence of the recombinant ketoreductase is shown by any one of SEQ ID No.2, 4, 6, 8 and 10. A product is obtained in a reaction carried out by mixing the recombinant ketoreductase, 3-quinuclidone or 3-quinuclidinone hydrochloride, a cofactor, a buffer, a recombinant glucose dehydrogenase and glucose in a proportion.
(FR) La présente invention concerne des applications d'une cétoréductase recombinante dans la préparation de (R)-3-quinuclidinol. La séquence d'acides aminés de la cétoréductase recombinante est représentée par l'une quelconque des SEQ ID no : 2, 4, 6, 8 et 10. Un produit est obtenu dans une réaction réalisée en mélangeant la cétoréductase recombinante, de la 3-quinuclidone ou du chlorhydrate de 3-quinuclidinone, un cofacteur, un tampon, une glucose déshydrogénase recombinante et du glucose en une certaine proportion.
(ZH) 提供一种重组酮还原酶在制备(R)-3-奎宁醇中的应用,其中重组酮还原酶的氨基酸序列如SEQ ID No.2、4、6、8、10中任一项所示,将重组酮还原酶、3-奎宁环酮或3-奎宁环酮盐酸盐、辅因子、缓冲液、重组葡萄糖脱氢酶、葡萄糖按一定比例混合反应得到产物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)