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1. (WO2017202185) PERIPHERAL BLOOD GENE MARKER FOR SCREENING BENIGN AND MALIGNANT SMALL PULMONARY NODULES AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/202185 International Application No.: PCT/CN2017/083019
Publication Date: 30.11.2017 International Filing Date: 04.05.2017
IPC:
C12Q 1/68 (2006.01) ,C12N 15/11 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
Applicants: SHANGHAI BIOMEDICAL LABORATORY CO., LTD.[CN/CN]; 1st Floor No.26&28, Jiangchangsan Road, Jingan District Shanghai 200436, CN
Inventors: CHENG, Changming; CN
YANG, Chao; CN
Agent: SHULUN & PARTNERS (SHANGHAI); Suite 1104A No.333 Zhaojiabang Road, Xuhui District Shanghai 200032, CN
Priority Data:
201610353398.625.05.2016CN
Title (EN) PERIPHERAL BLOOD GENE MARKER FOR SCREENING BENIGN AND MALIGNANT SMALL PULMONARY NODULES AND USE THEREOF
(FR) MARQUEUR DE GÈNE DU SANG PÉRIPHÉRIQUE POUR LE DÉPISTAGE DE PETITS NODULES PULMONAIRES BÉNINS ET MALINS ET SON UTILISATION
(ZH) 甄别肺部微小结节良恶性的外周血基因标志物及其用途
Abstract:
(EN) Provided is a group of peripheral blood gene markers for screening benign and malignant small pulmonary nodules, comprising: gene sequences characterized by micronodular lung carcinoma as shown in SEQ ID NOs. 1-6, wherein the gene sequences exhibit differential expression in the peripheral blood of micronodular lung carcinoma patients and non-micronodular lung carcinoma patients. In addition, also provided is the use of the above-mentioned gene markers in preparing a product for early screening micronodular lung carcinoma.
(FR) La présente invention porte sur un groupe de marqueurs de gène du sang périphérique pour le criblage de petits nodules pulmonaires bénins et malins, comprenant : des séquences de gènes caractérisées par un carcinome pulmonaire micronodulaire comme présenté dans les SEQ ID NO 1-6, où les séquences de gènes présentent une expression différentielle dans le sang périphérique de patients atteints de carcinome pulmonaire micronodulaire et de patients atteints de carcinome pulmonaire non micronodulaire. De plus, la présente invention concerne également l'utilisation des marqueurs de gène mentionnés ci-dessus dans la préparation d'un produit pour le dépistage précoce du carcinome pulmonaire micronodulaire.
(ZH) 一组甄别肺部微小结节良恶性的外周血基因标志物,包含:SEQ ID NO.1~SEQ ID NO.6所示的微小结节肺癌特征基因序列,该基因序列在微小结节肺癌患者与非微小结节肺癌患者的外周血中差异表达。另外还提供了上述基因标志物在制备微小结节肺癌早期筛查产品中的用途。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)