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1. (WO2017201579) ARTHROGENIC ALPHAVIRUS VACCINE

Pub. No.:    WO/2017/201579    International Application No.:    PCT/AU2017/050489
Publication Date: Fri Dec 01 00:59:59 CET 2017 International Filing Date: Fri May 26 01:59:59 CEST 2017
IPC: C07K 14/18
C07K 16/10
C12N 15/40
C07K 19/00
A61K 38/16
A61K 39/42
A61P 31/14
G01N 33/68
Applicants: GRIFFITH UNIVERSITY
Inventors: MAHALINGAM, Surendran
TAYLOR, Adam
Title: ARTHROGENIC ALPHAVIRUS VACCINE
Abstract:
The invention relates to a vaccine comprising live attenuated recombinant alphavirus comprising mutated capsid protein. The invention also relates to a method of preventing a subject from contracting an alphaviral infection that would otherwise produce clinical signs of disease. In an embodiment the mutated capsid protein is Chikungunya virus (CHIKV) capsid protein having a mutated nucleolar localisation signal/sequence (NoLS), preferably the mutant NLS 101/95.