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1. (WO2017201579) ARTHROGENIC ALPHAVIRUS VACCINE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/201579    International Application No.:    PCT/AU2017/050489
Publication Date: 30.11.2017 International Filing Date: 25.05.2017
IPC:
C07K 14/18 (2006.01), C07K 16/10 (2006.01), C12N 15/40 (2006.01), C07K 19/00 (2006.01), A61K 38/16 (2006.01), A61K 39/42 (2006.01), A61P 31/14 (2006.01), G01N 33/68 (2006.01)
Applicants: GRIFFITH UNIVERSITY [AU/AU]; 170 Kessels Road Nathan, Queensland 4111 (AU)
Inventors: MAHALINGAM, Surendran; (AU).
TAYLOR, Adam; (AU)
Agent: CULLENS PTY LTD; Level 32, 239 George Street Brisbane, Queensland 4000 (AU)
Priority Data:
2016902014 27.05.2016 AU
2017900446 13.02.2017 AU
Title (EN) ARTHROGENIC ALPHAVIRUS VACCINE
(FR) VACCIN CONTRE L'ALPHAVIRUS ARTHROGÈNE
Abstract: front page image
(EN)The invention relates to a vaccine comprising live attenuated recombinant alphavirus comprising mutated capsid protein. The invention also relates to a method of preventing a subject from contracting an alphaviral infection that would otherwise produce clinical signs of disease. In an embodiment the mutated capsid protein is Chikungunya virus (CHIKV) capsid protein having a mutated nucleolar localisation signal/sequence (NoLS), preferably the mutant NLS 101/95.
(FR)L'invention concerne un vaccin comprenant un alphavirus recombinant atténué vivant comprenant une protéine de capside mutée. L'invention concerne également un procédé pour empêcher un sujet de contracter une infection alphavirale qui serait par ailleurs susceptible de produire des signes cliniques de maladie. Dans un mode de réalisation, la protéine de capside mutée est une protéine de capside du virus Chikungunya (CHIKV) ayant un signal/séquence de localisation nucléolaire muté (NoLS), de préférence le mutant NLS 101/95.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)