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1. (WO2017201546) SYSTEMS AND METHODS FOR AUTOMATED SINGLE CELL CYTOLOGICAL CLASSIFICATION IN FLOW
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Pub. No.: WO/2017/201546 International Application No.: PCT/US2017/033889
Publication Date: 23.11.2017 International Filing Date: 22.05.2017
IPC:
G01N 15/14 (2006.01) ,C12M 1/34 (2006.01) ,G01N 15/02 (2006.01) ,G01N 15/10 (2006.01) ,G01N 33/48 (2006.01) ,G01N 33/487 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15
Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10
Investigating individual particles
14
Electro-optical investigation
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
34
Measuring or testing with condition measuring or sensing means, e.g. colony counters
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15
Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
02
Investigating particle size or size distribution
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15
Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10
Investigating individual particles
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
487
of liquid biological material
Applicants:
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; Office of General Counsel, Building 170 3rd Floor, Main Quad P.O. Box 20386 Stanford, CA 94305-2038, US
Inventors:
MASAELI, Mahdokht; US
SALEK, Mahyar; US
ASHLEY, Euan, A.; US
Agent:
HOANG, Loi, T.; US
Priority Data:
62/339,30520.05.2016US
Title (EN) SYSTEMS AND METHODS FOR AUTOMATED SINGLE CELL CYTOLOGICAL CLASSIFICATION IN FLOW
(FR) SYSTÈMES ET PROCÉDÉS DE CLASSIFICATION CYTOLOGIQUE AUTOMATISÉE DE CELLULES UNIQUES EN ÉCOULEMENT
Abstract:
(EN) Systems and methods in accordance with various embodiments of the invention are capable of rapid analysis and classification of cellular samples based on cytomorphological properties. In several embodiments, cells suspended in a fluid medium are passed through a microfluidic channel, where they are focused to a single stream line and imaged continuously. In a number of embodiments, the microfluidic channel establishes flow that enables individual cells to each be imaged at multiple angles in a short amount of time. A pattern recognition system can analyze the data captured from high-speed images of cells flowing through this system and classify target cells. In this way, the automated platform creates new possibilities for a wide range of research and clinical applications such as (but not limited to) point of care services.
(FR) Des systèmes et des procédés selon divers modes de réalisation de l'invention sont aptes à une analyse et une classification rapides d'échantillons cellulaires sur la base de propriétés cytomorphologiques. Dans plusieurs modes de réalisation, des cellules en suspension dans un milieu fluide passent à travers un canal microfluidique, où elles sont focalisées sur une seule ligne de flux et imagées en continu. Dans un certain nombre de modes de réalisation, le canal microfluidique établit un écoulement qui permet à des cellules individuelles d'être imagées selon des angles multiples en peu de temps. Un système de reconnaissance de motif peut analyser les données capturées à partir d'images à haute vitesse de cellules circulant à travers ce système et classer des cellules cibles. De cette manière, la plate-forme automatisée crée de nouvelles possibilités pour une large gamme d'applications de recherche et cliniques telles que (mais sans s'y limiter) des services de point d'intervention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)