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1. (WO2017201531) PHOTOACTIVE FLUOROPHORES AND METHODS OF IN VIVO LABELING
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Pub. No.: WO/2017/201531 International Application No.: PCT/US2017/033842
Publication Date: 23.11.2017 International Filing Date: 22.05.2017
IPC:
G01N 21/64 (2006.01) ,C07D 311/80 (2006.01) ,C09B 11/24 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
62
Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63
optically excited
64
Fluorescence; Phosphorescence
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
78
Ring systems having three or more relevant rings
80
Dibenzopyrans; Hydrogenated dibenzopyrans
C CHEMISTRY; METALLURGY
09
DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
B
ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
11
Diaryl- or triarylmethane dyes
04
derived from triarylmethanes
10
Amino derivatives of triarylmethanes
24
Phthaleins containing amino groups
Applicants:
HOWARD HUGHES MEDICAL INSTITUTE [US/US]; 4000 Jones Bridge Road Chevy Chase, Maryland 20815-6789, US
Inventors:
LAVIS, Luke D.; US
GRIMM, Jonathan B.; US
Agent:
DECKER, Mandy W.; US
WRIGHT, Terry L.; US
NAGLE, JR., David W.; US
HAEBERLIN, Jeffrey A.; US
Priority Data:
62/339,64320.05.2016US
Title (EN) PHOTOACTIVE FLUOROPHORES AND METHODS OF IN VIVO LABELING
(FR) FLUOROPHORES PHOTOACTIFS ET PROCÉDÉS DE MARQUAGE IN VIVO
Abstract:
(EN) Provided are a photoactive fluorophore, a photoactive ligand, and a photoactive complex. The photoactive fluorophore includes a photoactivatable derivative of an azetidine-containing Janelia-Fluor dye. The photoactive ligand includes a photoactive fluorophore and a protein tag. The photoactive complex includes a photoactive ligand conjugated to a protein. Also provided are methods of in vivo labeling with and photoactivation of the photoactive fluorophore, ligand, and complex.
(FR) La présente invention concerne un fluorophore photoactif, un ligand photoactif et un complexe photoactif. Le fluorophore photoactif comprend un dérivé photoactivable d'un colorant Janelia Fluor comportant de l'azétidine. Le ligand photoactif comprend un fluorophore photoactif et un marqueur protéique. Le complexe photoactif comprend un ligand photoactif conjugué à une protéine. L'invention concerne également des procédés de marquage in vivo par photoactivation du fluorophore photoactif, du ligand et du complexe.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)