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1. (WO2017201493) SINGLE CHAIN VARIABLE FRAGMENT CD3 BINDING PROTEINS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/201493    International Application No.:    PCT/US2017/033673
Publication Date: 23.11.2017 International Filing Date: 19.05.2017
IPC:
A61K 39/395 (2006.01), C07K 16/18 (2006.01), C07K 16/28 (2006.01)
Applicants: HARPOON THERAPEUTICS, INC. [US/US]; 4000 Shoreline Court, Suite 250 South San Francisco, California 94080 (US)
Inventors: DUBRIDGE, Robert B.; (US).
SETO, Pui; (US).
AUSTIN, Richard J.; (US).
EVNIN, Luke; (US).
GUENOT, Jeanmarie; (US).
LEMON, Bryan D.; (US)
Agent: LIN, Clark Y.; (US)
Priority Data:
62/339,685 20.05.2016 US
Title (EN) SINGLE CHAIN VARIABLE FRAGMENT CD3 BINDING PROTEINS
(FR) PROTÉINES SE LIANT AU FRAGMENT MONOCATÉNAIRE VARIABLE DE CD3
Abstract: front page image
(EN)Disclosed herein are single chain variable fragment CD3 binding proteins with improved binding affinities, and robust aggregation profiles. Also described are multispecific binding proteins comprising a single chain variable fragment CD3 binding protein according to the instant disclosure. Pharmaceutical compositions comprising the binding proteins disclosed herein and methods of using such formulations are provided.
(FR)La présente divulgation concerne des protéines se liant au fragment monocaténaire variable de CD3 ayant des affinités de liaison améliorées, et des profils d'agrégation robustes. La présente divulgation concerne également des protéines de liaison multispécifiques dont une protéine se liant au fragment monocaténaire variable de CD3. Des compositions pharmaceutiques comprenant les présentes protéines de liaison et des procédés d'utilisation desdites formulations sont en outre décrits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)