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1. (WO2017201449) PROTAC ANTIBODY CONJUGATES AND METHODS OF USE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/201449    International Application No.:    PCT/US2017/033611
Publication Date: 23.11.2017 International Filing Date: 19.05.2017
IPC:
A61K 47/54 (2017.01), A61K 47/68 (2017.01), A61P 35/00 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080 (US) (AE, AG, AM, AO, AU, AZ, BA, BB, BF, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CI, CL, CM, CO, CR, CU, DJ, DM, DO, DZ, EC, EG, GA, GD, GE, GH, GM, GN, GQ, GT, GW, HN, ID, IL, IR, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LY, MA, MD, ME, MG, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NZ, OM, PA, PE, PG, PH, QA, RU, RW, SA, SC, SD, SG, SL, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW only).
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel (CH) (AL, AT, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR only)
Inventors: PILLOW, Thomas; (US).
SADOWSKY, Jack; (US).
STABEN, Leanna; (US).
STABEN, Steven; (US).
WEI, Binqing; (US).
WERTZ, Ingrid; (US).
ADHIKARI, Pragya; (US).
BLAQUIERE, Nicole; (US).
DRAGOVICH, Peter; (US).
FAIRBROTHER, Wayne; (US)
Agent: CRISSEY, Todd, M.; (US).
ACKERMAN, Lily J.; (US).
ANDRUS, Alex; (US).
AUSENHUS, Scott L.; (US).
BERENDT, Frank JN; (US).
BUCKWALTER, Brian L.; (US).
CHANG, Y. Elaine; (US).
CHI, I. Shannon; (US).
COBURN, Cara M.; (US).
COULTER, Kathryn L.; (US).
DAVIS, Jennifer L.; (US).
DUFFIELD, Jonathan J.; (US).
FANG, Carol A.; (US).
GHOSE, Shameek; (US).
HALL, Robert C.; (US).
HEIDER, Julie A.; (US).
HOLMES, Jennifer K.; (US).
JOHNSTON, Sean A.; (US).
KAFKA, Mark D.; (US).
KALE, Tamara; (US).
KALINOWSKI, Grant E.; (US).
KUBINEC, Jeffrey S.; (US).
LEE, Wendy M.; (US).
LI, Qianru; (US).
MARSCHANG, Diane L.; (US).
MARTINEAU, Janet M.; (US).
MCCLELLAN, Kelly B.; (US).
NAIK, Paul S.; (US).
NESBITT, James E.; (US).
PAZDERA, R. Minako; (US).
PENG, Tony W.; (US).
RICHARDSON, Jessica L.; (US).
ROPP, Traci H.; (US).
SCHWARTZ, Timothy R.; (US).
SHERMAN, Daniel E.; (US).
SHIN, Elinor K.; (US).
TAN, Anna M.; (US).
WAIS, Rebecca J.; (US).
YEUNG, Bonny G.; (US).
YONKER, Stephanie A.; (US)
Priority Data:
62/339,257 20.05.2016 US
Title (EN) PROTAC ANTIBODY CONJUGATES AND METHODS OF USE
(FR) CONJUGUÉS ANTICORPS-PROTAC ET PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)The subject matter described herein is directed to antibody-PROTAC conjugates (PACs), to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where targeted protein degradation is beneficial.
(FR)La présente invention concerne des conjugués anticorps-PROTAC (PAC), des compositions pharmaceutiques les contenant, et leur utilisation dans le traitement de maladies et de troubles dans lesquels la dégradation ciblée des protéines est bénéfique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)