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1. (WO2017201313) NOVEL MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER
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Pub. No.: WO/2017/201313 International Application No.: PCT/US2017/033372
Publication Date: 23.11.2017 International Filing Date: 18.05.2017
IPC:
C07D 471/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY [US/US]; 83 Somerset Street New Brunswick, NJ 08901, US
Inventors:
JIN, Shengkan; US
CAO, Bin; US
AUGERI, David J.; US
TAO, Hanlin; US
Agent:
MANDELBLATT, Jill; US
Priority Data:
62/338,19018.05.2016US
Title (EN) NOVEL MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER
(FR) NOUVEAUX DÉCOUPLANTS MITOCHONDRIAUX POUR LE TRAITEMENT DE MALADIES MÉTABOLIQUES ET DU CANCER
Abstract:
(EN) The present disclosure relates to benzamide compounds, prodrugs of the compounds, pharmaceutical compositions containing the compounds and/or the prodrugs and methods of using the compounds, prodrugs and pharmaceutical compositions in the treatment of diseases related to lipid metabolism including diabetes, Non-Alcholic Fatty Liver Disease (NAFLD), Non-Alcholic Steathohepatitis (NASH), diseases caused by abnormal cell proliferation including cancer, psoriasis, and infectious diseases.
(FR) La présente invention concerne des composés de benzamide, des promédicaments des composés, des compositions pharmaceutiques contenant les composés et/ou les promédicaments et des procédés d'utilisation des composés, des promédicaments et des compositions pharmaceutiques dans le traitement de maladies liées au métabolisme des lipides, y compris le diabète, la maladie du foie gras non alcoolique, la stéato-hépatite non alcoolique, les maladies provoquées par une prolifération cellulaire anormale, y compris le cancer, le psoriasis et les maladies infectieuses.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)