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1. (WO2017201278) THIOESTER PRODRUGS OF MACROCYCLES AS INHIBITORS OF HISTONE DEACETYLASES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/201278    International Application No.:    PCT/US2017/033316
Publication Date: 23.11.2017 International Filing Date: 18.05.2017
IPC:
A61K 38/12 (2006.01), C07K 11/02 (2006.01)
Applicants: ONKURE, INC. [US/US]; 1067 South Hover Street Longmont, Colorado 80501 (US)
Inventors: PISCOPIO, Anthony D.; (US)
Agent: LOWEN, Gregory T.; (US).
SMYTH, Robert J.; (US).
BUCK, Todd B.; (US).
LEE, Janice H.; (US)
Priority Data:
62/339,772 20.05.2016 US
Title (EN) THIOESTER PRODRUGS OF MACROCYCLES AS INHIBITORS OF HISTONE DEACETYLASES
(FR) PROMÉDICAMENTS MACROCYCLIQUES DE TYPE THIOESTER À TITRE D'INHIBITEURS D'HISTONE DÉSACÉTYLASES
Abstract: front page image
(EN)The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.
(FR)La présente invention concerne un nouveau composé de promédicament macrocyclique de Formule générale (I), une composition pharmaceutique le contenant, et une méthode de traitement des maladies médiées par les enzymes HDAC par administration d'un composé de formule (I), où R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A et Z sont tels que définis dans la description.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)