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1. (WO2017201276) METHODS OF DETECTING A MUTATED GENE BY MULTIPLEX DIGITAL PCR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/201276    International Application No.:    PCT/US2017/033314
Publication Date: 23.11.2017 International Filing Date: 18.05.2017
IPC:
C12Q 1/68 (2006.01), C12P 19/34 (2006.01), G01N 21/64 (2006.01)
Applicants: CORNELL UNIVERSITY [US/US]; Center for Technology Licensing at Cornell University (CTL) 395 Pine Tree Road Suite 310 Ithaca, New York 14850 (US)
Inventors: HASSANE, Duane; (US)
Agent: GROLZ, Edward W.; (US)
Priority Data:
62/338,058 18.05.2016 US
Title (EN) METHODS OF DETECTING A MUTATED GENE BY MULTIPLEX DIGITAL PCR
(FR) PROCÉDÉS DE DÉTECTION D'UN GÈNE MUTÉ PAR PCR NUMÉRIQUE MULTIPLEX
Abstract: front page image
(EN)The present disclosure is directed to digital PCR (dPCR)-based methods and kits for detecting and quantifying mutant nucleic acids (e.g., transcripts) of a gene containing insertions at specific locations. In some embodiments, the method permits sensitive detection and quantitation of mutant NPM1 nucleic acids comprising insertion mutations (NPM1mut subtypes).
(FR)La présente invention concerne des procédés et des trousses basés sur la PCR numérique (dPCR) pour détecter et quantifier des acides nucléiques mutants (par exemple, des transcrits) d'un gène contenant des insertions à des emplacements spécifiques. Dans certains modes de réalisation, le procédé permet la détection sensible et la quantification d'acides nucléiques NPM1 mutants comprenant des mutations par insertion (sous-types de NPM1mut).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)