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1. (WO2017201165) METHODS FOR SUBTYPING OF LUNG ADENOCARCINOMA
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/201165    International Application No.:    PCT/US2017/033110
Publication Date: 23.11.2017 International Filing Date: 17.05.2017
IPC:
C12Q 1/68 (2006.01), C07K 16/30 (2006.01), A61K 38/18 (2006.01)
Applicants: GENECENTRIC THERAPEUTICS, INC. [US/US]; 79 TW Alexander Drive 4401 Research Commons, Suite 105 Research Triangle Park, NC 27709 (US).
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US/US]; 100 Europa Drive Suite 430 Chapel Hill, North Carolina 27517 (US)
Inventors: FARUKI, Hawazin; (US).
LAI-GOLDMAN, Myla; (US).
MAYHEW, Greg; (US).
SERODY, Jonathan; (US).
PEROU, Charles; (US).
HAYES, David Neil; (US)
Agent: MCEVOY, Michael T.; (US).
TUSCAN, Michael S.; (US)
Priority Data:
62/337,591 17.05.2016 US
62/337,645 17.05.2016 US
62/396,587 19.09.2016 US
62/420,836 11.11.2016 US
62/425,717 23.11.2016 US
Title (EN) METHODS FOR SUBTYPING OF LUNG ADENOCARCINOMA
(FR) PROCÉDÉS POUR SOUS-TYPAGE D'ADÉNOCARCINOME PULMONAIRE
Abstract: front page image
(EN)Methods and compositions are provided for determining a subtype of lung adenocarcinoma (AD) of an individual by detecting the expression level of at least one classifier biomarker selected from a group of gene signatures for lung adenocarcinoma. Also provided herein are methods and compositions for determining the response of an individual with an adenocarcinoma subtype to a therapy such as immunotherapy.
(FR)L'invention porte sur des procédés et des compositions pour déterminer un sous-type d'adénocarcinome pulmonaire (AD) d'un individu par la détection du niveau d'expression d'au moins un biomarqueur de classificateur sélectionné dans un groupe de signatures géniques pour adénocarcinome pulmonaire. L'invention concerne également des procédés et des compositions permettant de déterminer la réponse d'un individu ayant un sous-type d'adénocarcinome à une thérapie telle qu'une immunothérapie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)