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1. (WO2017201152) ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF

Pub. No.:    WO/2017/201152    International Application No.:    PCT/US2017/033078
Publication Date: Fri Nov 24 00:59:59 CET 2017 International Filing Date: Thu May 18 01:59:59 CEST 2017
IPC: A61K 31/551
A61K 31/42
A61K 31/496
Applicants: ENANTA PHARMACEUTICALS, INC.
Inventors: OR, Yat Sun
HE, Yong
SHEN, Ruichao
XING, Xuechao
GRANGER, Brett
WANG, Bin
MA, Jun
HE, Jing
LONG, Jiang
WANG, Guoqiang
Title: ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
Abstract:
The present invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated as FXR modulators. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR, and methods for their preparation and use.