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1. (WO2017201152) ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/201152    International Application No.:    PCT/US2017/033078
Publication Date: 23.11.2017 International Filing Date: 17.05.2017
IPC:
A61K 31/551 (2006.01), A61K 31/42 (2006.01), A61K 31/496 (2006.01)
Applicants: ENANTA PHARMACEUTICALS, INC. [US/US]; 500 Arsenal Street Watertown, MA 02472 (US)
Inventors: OR, Yat Sun; (US).
HE, Yong; (US).
SHEN, Ruichao; (US).
XING, Xuechao; (US).
GRANGER, Brett; (US).
WANG, Bin; (US).
MA, Jun; (US).
HE, Jing; (US).
LONG, Jiang; (US).
WANG, Guoqiang; (US)
Agent: HARLAN, Edgar, W.; (US)
Priority Data:
62/337,933 18.05.2016 US
Title (EN) ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
(FR) DÉRIVÉS D'ISOXAZOLE UTILISÉS COMME AGONISTES DE FXR ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)The present invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated as FXR modulators. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR, and methods for their preparation and use.
(FR)La présente invention concerne des composés de Formule I, et les sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques comprenant ces composés et des méthodes d'utilisation de ces composés pour traiter ou prévenir une maladie ou un trouble à médiation par FXR. Spécifiquement, la présente invention concerne des dérivés d'isoxazole utiles en tant qu'agonistes de FXR, et des procédés pour leur préparation et leur utilisation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)