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1. (WO2017201131) VARIANT PD-L1 POLYPEPTIDES, T-CELL MODULATORY MULTIMERIC POLYPEPTIDES, AND METHODS OF USE THEREOF

Pub. No.:    WO/2017/201131    International Application No.:    PCT/US2017/033042
Publication Date: Fri Nov 24 00:59:59 CET 2017 International Filing Date: Thu May 18 01:59:59 CEST 2017
IPC: A61K 39/395
C07K 14/705
C07K 16/28
Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
Inventors: GARRETT-THOMSON, Sarah, C.
ALMO, Steven, C.
SEIDEL, Ronald, D.
Title: VARIANT PD-L1 POLYPEPTIDES, T-CELL MODULATORY MULTIMERIC POLYPEPTIDES, AND METHODS OF USE THEREOF
Abstract:
The present disclosure provides variant PD-L1 immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T- cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.