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1. (WO2017201126) THREE-DIMENSIONAL PLATFORM FOR TESTING THERAPEUTIC RESPONSES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/201126    International Application No.:    PCT/US2017/033031
Publication Date: 23.11.2017 International Filing Date: 17.05.2017
IPC:
C12M 1/34 (2006.01), C12M 3/00 (2006.01), C12N 5/00 (2006.01), C12N 5/02 (2006.01), C12N 5/06 (2006.01), G01N 33/53 (2006.01), G01N 33/574 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 412 Low Memorial Library 535 W. 116th Street New York, New York 10027 (US)
Inventors: KAUFMAN, Laura; (US).
GUZMAN, Asja; (US)
Agent: HOOPER, Kevin C.; (US)
Priority Data:
62/339,712 20.05.2016 US
62/420,402 10.11.2016 US
Title (EN) THREE-DIMENSIONAL PLATFORM FOR TESTING THERAPEUTIC RESPONSES
(FR) PLATEFORME TRIDIMENSIONNELLE POUR TESTER DES RÉPONSES THÉRAPEUTIQUES
Abstract: front page image
(EN)An in vitro system is provided for evaluating a therapeutic response to a candidate therapeutic agent. The system includes a multicellular aggregate, a cell-bound layer of basement membrane surrounding the multicellular aggregate, and a three-dimensional (3-D) biopolymer matrix, wherein the multicellular aggregate and the cell-bound layer of basement membrane are disposed within the 3-D biopolymer matrix. Methods of using the system are also provided, including methods of diagnosing and treating a cancer in a subject.
(FR)L'invention porte sur un système in vitro pour évaluer une réponse thérapeutique à un agent thérapeutique candidat. Le système comprend un agrégat multicellulaire, une couche liée aux cellules de membrane basale entourant l'agrégat multicellulaire et une matrice tridimensionnelle (3-D) de biopolymère, l'agrégat multicellulaire et la couche liée aux cellules de la membrane basale étant disposés au sein de la matrice 3-D de biopolymère. L'invention concerne également des procédés d'utilisation du système, y compris des procédés de diagnostic et de traitement d'un cancer chez un sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)