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1. (WO2017201036) STROMAL GENE SIGNATURES FOR DIAGNOSIS AND USE IN IMMUNOTHERAPY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/201036    International Application No.:    PCT/US2017/032890
Publication Date: 23.11.2017 International Filing Date: 16.05.2017
IPC:
C12Q 1/68 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, CA 94080-4990 (US) (AE, AG, AM, AO, AU, AZ, BB, BF, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CI, CL, CM, CO, CR, CU, DJ, DM, DO, DZ, EC, EG, GA, GD, GE, GH, GM, GN, GQ, GT, GW, HN, ID, IL, IR, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LY, MA, MD, ME, MG, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NZ, OM, PA, PE, PG, PH, QA, RU, RW, SA, SC, SD, SG, SL, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW only).
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel (CH) (AL, AT, BA, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR only)
Inventors: HEGDE, Priti; (US).
MOLINERO, Luciana; (US).
MARIATHASAN, Sanjeev; (US).
TURLEY, Shannon; (US).
ASTARITA, Jillian; (US).
CUBAS, Rafael; (US).
YANG, Yagai; (US)
Agent: DONAHUE, Brian, A.; (US).
AIKEN, Charity; (US).
AHN, Sejin; (US).
BANKO, Max; (US).
ARJOMAND, Mehran; (US)
Priority Data:
62/337,815 17.05.2016 US
Title (EN) STROMAL GENE SIGNATURES FOR DIAGNOSIS AND USE IN IMMUNOTHERAPY
(FR) SIGNATURES GÉNÉTIQUES STROMALES DESTINÉES AU DIAGNOSTIC ET À L’UTILISATION EN IMMUNOTHÉRAPIE
Abstract: front page image
(EN)The invention provides methods for identifying an individuals with a disease or disorder who is less likely to respond to immunotherapy alone, the method comprising determining the presence of a stromal gene signature in a sample from the individual, said signature comprising one or more of FAP, FN1, MMP2, PDGFRB, or THY, wherein an increase in the level of expression of the one or more genes in the stroma gene signature relative to a median level identifies an individual for treatment with an immunotherapy and with a suppressive stromal antagonist. In some aspects, the invention provides methods for treating an individual displaying the stromal gene signature. In other aspects, the invention provides kits for determining the presence of a stroma gene signature in a sample from an individual.
(FR)La présente invention concerne des procédés d’identification d’individus souffrant d’une maladie ou d’un trouble qui est moins susceptible de répondre à l’immunothérapie seule, le procédé comprenant la détermination de la présence d’une signature génétique stromale dans un échantillon provenant de l’individu, ladite signature comprenant un ou plusieurs parmi FAP, FN1, MMP2, PDGFRB, ou THY, une augmentation du niveau d’expression du ou des gènes dans la signature génétique stromale par rapport à un niveau médian identifiant un individu pour le traitement comportant une immunothérapie et comportant un antagoniste stromal suppressif. Dans certains aspects, l’invention concerne des procédés de traitement d’un individu affichant la signature génétique stromale. Dans d’autres aspects, l’invention concerne des kits de détermination de la présence d’une signature génétique stromale dans un prélèvement provenant d’un individu.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)