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1. (WO2017200984) NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF
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Pub. No.: WO/2017/200984 International Application No.: PCT/US2017/032811
Publication Date: 23.11.2017 International Filing Date: 16.05.2017
IPC:
C07K 7/64 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
64
Cyclic peptides containing only normal peptide links
Applicants:
S&T GLOBAL INC. [US/US]; 470 Wildwood Avenue Woburn, MA 01801, US
Inventors:
SU, Zhuang; US
YANG, Suizhou; US
LONG, Zhengyu; US
Agent:
SUPERKO, Colleen; US
BARAZESH, Ellyar, Y.; US
BEVILACQUA, Michael, J.; US
ALLEN, Owen, K.; US
ANDERSON, Thomas, E.; US
Priority Data:
62/337,37717.05.2016US
62/339,46420.05.2016US
62/384,82208.09.2016US
Title (EN) NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF
(FR) NOUVEAUX DÉRIVÉS DE CYCLOSPORINE ET LEURS UTILISATIONS
Abstract:
(EN) A compound of the Formula (I) is disclosed: (I) or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification. Also described are a pharmaceutical composition comprising the same and a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, lung, and liver, and kindey diseases, and hair loss using the same.
(FR) La présente invention concerne un composé de formule (I) : (I) ou un sel pharmaceutiquement acceptable de celui-ci, les symboles étant tels que définis dans la description. L'invention concerne également une composition pharmaceutique comprenant ledit composé et un procédé de traitement ou de prévention d'infections virales, d'inflammations, de sécheresse oculaire, de troubles du système nerveux central, des maladies cardio-vasculaires, du cancer, de l'obésité, du diabète, de la dystrophie musculaire, de maladies pulmonaires, hépatiques et rénales ainsi que de la chute des cheveux à l'aide de ceux-ci.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)