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1. (WO2017200970) POTENT AND SELECTIVE MU OPIOID RECEPTOR MODULATORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/200970 International Application No.: PCT/US2017/032792
Publication Date: 23.11.2017 International Filing Date: 16.05.2017
IPC:
A61K 31/485 (2006.01) ,C07D 489/08 (2006.01)
Applicants: VIRGINIA COMMONWEALTH UNIVERSITY[US/US]; 800 East Leigh Street Suite 3000 Richmond, VA 23298, US
Inventors: ZHANG, Yan; US
SELLEY, Dana, E.; US
DEWEY, William; US
ABKARALI, Hamid; US
Agent: WHITHAM, Michael, E.; US
Priority Data:
62/338,63619.05.2016US
Title (EN) POTENT AND SELECTIVE MU OPIOID RECEPTOR MODULATORS
(FR) MODULATEURS PUISSANTS ET SÉLECTIFS DES RÉCEPTEURS OPIOÏDES MU
Abstract:
(EN) Analogues of 6 α/β-naltrexamine (NAQ) are provided. The analogues are selective, reversible antagonists of the mu opioid receptor (MOR) that exhibit good blood brain barrier penetration. The compounds are used in the treatment of opioid addiction and other diseases and conditions, including for the treatment of pain.
(FR) L'invention concerne des analogues de l’α/β-naltrexamine 6 (NAQ). Lesdits analogues sont des antagonistes sélectifs et réversibles du récepteur opioïde mu (MOR) qui permettent une bonne pénétration de la barrière hémato-encéphalique. Ces composés sont utilisés dans le traitement de la dépendance aux opioïdes et d'autres maladies et affections, y compris pour le traitement de la douleur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)