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1. (WO2017200884) MICROORGANISM WITH MODIFIED ALDEHYDE:FERREDOXIN OXIDOREDUCTASE ACTIVITY AND RELATED METHODS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/200884    International Application No.:    PCT/US2017/032564
Publication Date: 23.11.2017 International Filing Date: 12.05.2017
IPC:
C12N 1/20 (2006.01), C12P 7/06 (2006.01), C12N 9/04 (2006.01), C12N 9/02 (2006.01)
Applicants: LANZATECH, INC. [US/US]; 8045 Lamon Avenue, Suite 400 Skokie, Illinois 60077 (US)
Inventors: LIEW, Fungmin; (US).
KOEPKE, Michael; (US)
Agent: SCHOEN, Andrea E.; (US)
Priority Data:
62/336,639 14.05.2016 US
Title (EN) MICROORGANISM WITH MODIFIED ALDEHYDE:FERREDOXIN OXIDOREDUCTASE ACTIVITY AND RELATED METHODS
(FR) MICRO-ORGANISME À ACTIVITÉ ALDÉHYDE/FERRÉDOXINE OXYDORÉDUCTASE MODIFIÉE ET PROCÉDÉS ASSOCIÉS
Abstract: front page image
(EN)The invention provides a non-naturally occurring bacterium having decreased or eliminated activity of an enzyme that catalyzes the reaction defined by EC 1.2.7.5, such as aldehyde:ferredoxin oxidoreductase (AOR). Optionally, the bacterium also has decreased or eliminated activity of an enzyme that catalyzes the reaction defined by EC 1.2.1.10 and/or EC 1.1.1.1, such as aldehyde dehydrogenase, alcohol dehydrogenase, or bifunctional aldehyde/alcohol dehydrogenase. The invention further provides methods of producing products by culturing the bacterium in the presence of a gaseous substrate containing one or more of CO, CO2, and H2.
(FR)L'invention concerne une bactérie non naturelle ayant une activité réduite ou éliminée d'une enzyme qui catalyse la réaction définie par EC 1.2.7.5, telle que l'aldéhyde/ferrédoxine oxydoréductase (AOR) En option, la bactérie a également une activité réduite ou éliminée d'une enzyme qui catalyse la réaction définie par EC 1.2.1.10 et/ou EC 1.1.1.1, telle que l'aldéhyde déshydrogénase, l'alcool déshydrogénase, ou l'aldéhyde/alcool déshydrogénase bifonctionnelle. L'invention concerne en outre des procédés de production de produits par culture de la bactérie en présence d'un substrat gazeux contenant un ou plusieurs des éléments suivants : CO, CO2 et H2
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)