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1. (WO2017200884) MICROORGANISM WITH MODIFIED ALDEHYDE:FERREDOXIN OXIDOREDUCTASE ACTIVITY AND RELATED METHODS

Pub. No.:    WO/2017/200884    International Application No.:    PCT/US2017/032564
Publication Date: Fri Nov 24 00:59:59 CET 2017 International Filing Date: Sat May 13 01:59:59 CEST 2017
IPC: C12N 1/20
C12P 7/06
C12N 9/04
C12N 9/02
Applicants: LANZATECH, INC.
Inventors: LIEW, Fungmin
KOEPKE, Michael
Title: MICROORGANISM WITH MODIFIED ALDEHYDE:FERREDOXIN OXIDOREDUCTASE ACTIVITY AND RELATED METHODS
Abstract:
The invention provides a non-naturally occurring bacterium having decreased or eliminated activity of an enzyme that catalyzes the reaction defined by EC 1.2.7.5, such as aldehyde:ferredoxin oxidoreductase (AOR). Optionally, the bacterium also has decreased or eliminated activity of an enzyme that catalyzes the reaction defined by EC 1.2.1.10 and/or EC 1.1.1.1, such as aldehyde dehydrogenase, alcohol dehydrogenase, or bifunctional aldehyde/alcohol dehydrogenase. The invention further provides methods of producing products by culturing the bacterium in the presence of a gaseous substrate containing one or more of CO, CO2, and H2.