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1. (WO2017200857) METHODS FOR USING TRIAZOLO-PYRAZINYL SOLUBLE GUANYLATE CYCLASE ACTIVATORS IN FIBROTIC DISORDERS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/200857    International Application No.:    PCT/US2017/032310
Publication Date: 23.11.2017 International Filing Date: 12.05.2017
IPC:
A61K 31/505 (2006.01), A61K 31/519 (2006.01), A61K 45/06 (2006.01), C07D 235/00 (2006.01), C07D 249/16 (2006.01), C07D 519/00 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US).
BERGER, Raphaelle [US/US]; (US) (US only).
DONG, Guizhen [US/US]; (US) (US only).
RAGHAVAN, Subharekha [US/US]; (US) (US only).
YANG, Zhiqiang [US/US]; (US) (US only)
Inventors: BERGER, Raphaelle; (US).
DONG, Guizhen; (US).
RAGHAVAN, Subharekha; (US).
YANG, Zhiqiang; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
62/338,076 18.05.2016 US
Title (EN) METHODS FOR USING TRIAZOLO-PYRAZINYL SOLUBLE GUANYLATE CYCLASE ACTIVATORS IN FIBROTIC DISORDERS
(FR) PROCÉDÉS D'UTILISATION D'ACTIVATEURS DE LA GUANYLATE CYCLASE SOLUBLE DANS LA TRIAZOLO-PYRAZINYLE POUR DES TROUBLES FIBROTIQUES
Abstract: front page image
(EN)Provided are methods for treating or preventing a fibrotic disease selected from systemic sclerosis, cystic fibrosis, non-alcoholic steatohepatitis, Peyronie's disease, or interstitial lung disease; the method comprising administering a therapeutically effective amount of a compound of Formula (I) (wherein R1, R2, R3, R4, and R5 are as herein described) or a pharmaceutically acceptable salt thereof, to a patient in need of such therapy.
(FR)L'invention concerne des procédés de traitement ou de prévention d'une maladie fibreuse choisie parmi la sclérose systémique, la mucoviscidose, la stéatohépatite non alcoolique, la maladie de La Peyronie ou la maladie pulmonaire interstitielle ; le procédé comprenant l’administration d’une quantité thérapeutiquement efficace d'un composé de formule (I) (R1, R2, R3, R4, et R5 étant tels que décrits dans la description) ou son sel pharmaceutiquement acceptable, à un patient ayant besoin d'une telle thérapie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)