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1. (WO2017200762) HUMAN AIRWAY STEM CELLS IN LUNG EPITHELIAL ENGINEERING

Pub. No.:    WO/2017/200762    International Application No.:    PCT/US2017/031076
Publication Date: Fri Nov 24 00:59:59 CET 2017 International Filing Date: Fri May 05 01:59:59 CEST 2017
IPC: A61K 35/12
A61K 35/42
C12M 3/00
C12N 5/00
C12N 5/071
Applicants: THE GENERAL HOSPITAL CORPORATION
GILPIN, Sarah E.
Inventors: GILPIN, Sarah E.
OTT, Harald C.
Title: HUMAN AIRWAY STEM CELLS IN LUNG EPITHELIAL ENGINEERING
Abstract:
Methods of using human airway stem cells in lung epithelial engineering, optionally wherein the cells are contacted with a gamma secretase inhibitor, bioartificial airway organs produced thereby, and the use thereof, e.g., for transplantation. Also methods of treating a bio-artificial matrix with Tenascin-C and/or fibrillin 2.