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1. (WO2017199811) CELL CULTURE MEDIUM FOR CULTURING ORGANOID, CULTURE METHOD, AND ORGANOID
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Pub. No.:    WO/2017/199811    International Application No.:    PCT/JP2017/017681
Publication Date: 23.11.2017 International Filing Date: 10.05.2017
Chapter 2 Demand Filed:    09.08.2017    
IPC:
C12N 1/00 (2006.01), C12N 5/071 (2010.01), C12N 5/074 (2010.01), C12N 5/09 (2010.01), C07K 14/475 (2006.01), C07K 14/51 (2006.01)
Applicants: KEIO UNIVERSITY [JP/JP]; 15-45, Mita 2-chome, Minato-ku, Tokyo 1088345 (JP)
Inventors: SATO Toshiro; (JP).
MATANO Mami; (JP)
Agent: TANAI Sumio; (JP).
IIDA Masato; (JP).
HARUTA Hirotaka; (JP).
YAMAGUCHI Yoh; (JP)
Priority Data:
2016-099995 18.05.2016 JP
Title (EN) CELL CULTURE MEDIUM FOR CULTURING ORGANOID, CULTURE METHOD, AND ORGANOID
(FR) MILIEU DE CULTURE CELLULAIRE POUR LA CULTURE D'UN ORGANOÏDE, PROCÉDÉ DE CULTURE ET ORGANOÏDE
(JA) オルガノイド培養用細胞培養培地、培養方法、及びオルガノイド
Abstract: front page image
(EN)A cell culture medium for culturing an organoid which comprises at least two members selected from the group consisting of insulin-like growth factor 1 (IGF1), fibroblast growth factor 2 (FGF2) and epiregulin (EREG), and at least one member selected from components i) to iii): i) a Wnt agonist; ii) a bone morphogenesis protein (BMP) inhibitor; and iii) a transforming growth factor-β (TGF-β) inhibitor.
(FR)L'invention concerne un milieu de culture cellulaire pour la culture d'un organoïde, qui comprend au moins deux éléments choisis dans le groupe constitué par le facteur 1 de croissance analogue à l'insuline (IGF1), le facteur 2 de croissance fibroblastique (FGF2) et l'épiréguline (EREG) et au moins un élément choisi parmi les constituants i) à iii) : i) un agoniste de Wnt ; ii) un inhibiteur de la protéine osseuse morphogénétique (BMP) ; et iii) un inhibiteur du facteur ß de croissance transformant (TGF-ß).
(JA)オルガノイド培養用細胞培養培地は、インスリン様成長因子1(Insulin-like growth factor1;IGF1)、線維芽細胞増殖因子2(Fibroblast growth factor 2;FGF2)、及びエピレグリン(Epiregulin;EREG)からなる群から選ばれる少なくとも二種、及び下記i)~iii)の成分のうち少なくとも一種を含む。i)Wntアゴニスト、ii)骨形成因子(bone morphogenetic protein;BMP)阻害剤、iii)形質転換増殖因子-β(transforming growth factor-β;TGF-β)阻害剤
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)