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1. (WO2017199067) BIOMARKERS SIGNATURE DISCOVERY AND SELECTION

Pub. No.:    WO/2017/199067    International Application No.:    PCT/IB2016/052936
Publication Date: Fri Nov 24 00:59:59 CET 2017 International Filing Date: Fri May 20 01:59:59 CEST 2016
IPC: G06F 19/18
G06F 19/24
Applicants: SIMPLICITYBIO SA
Inventors: BARRETO-SANZ, Miguel
PEÑA REYES, Carlos Andrés
Title: BIOMARKERS SIGNATURE DISCOVERY AND SELECTION
Abstract:
The present invention concerns a method for discovering at least a biomarkers signature from biomarker data pools, the method comprising the steps of: i) Generating a set of signatures (1, 2) with fuzzy logic and evolutionary algorithms, each signature reciting a determined number of biomarkers; ii) Selecting at least a target signature from said set of signatures by applying at least the following filters on said set of signatures (1, 2): a) a performance filter; b) a frequency filter; and c) a dominance filter. The present invention further relates to device for discovering at least a biomarkers signature from biomarker data pools and to a use of a biomarker signature discovered by a method according to the present invention for diagnosing, predicting or monitoring a disease.