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1. (WO2017199038) VACCINES

Pub. No.:    WO/2017/199038    International Application No.:    PCT/GB2017/051391
Publication Date: Fri Nov 24 00:59:59 CET 2017 International Filing Date: Fri May 19 01:59:59 CEST 2017
IPC: A61K 39/015
A61K 39/29
A61K 39/235
A61K 39/285
A61K 39/00
Applicants: OXFORD UNIVERSITY INNOVATION LIMITED
Inventors: REYES-SANDOVAL, Arturo
Title: VACCINES
Abstract:
The present invention relates to particles, particularly virus-like particles (VLPs), comprising fusion polypeptides comprising selected repeat units derived from the repeating regions of Type I and Type II circumsporozoite proteins(CSP) of Plasmodium vivax(Pv), together with an amino acid sequence derived from the C-terminal PvCSP sequence. In some embodiments, the fusion polypeptide additionally comprises an amino acid sequence derived from the N-terminal PvCSP sequenceand/or a surface antigen polypeptide derived from Hepatitis B virus (HBV-S). The invention also relates to nucleotide sequences coding for such fusion polypeptides, vectors and plasmids comprising such nucleotide sequences, and host cells comprising such vectors and plasmids. The invention additionally relates to compositions, particularly vaccine compositions, comprising the fusion polypeptides or VLPs for use as vaccines for the prevention of malaria.