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1. WO2017199033 - INTERMEDIATES FOR THE SYNTHESIS OF BILE ACID DERIVATIVES, IN PARTICULAR OF OBETICHOLIC ACID

Publication Number WO/2017/199033
Publication Date 23.11.2017
International Application No. PCT/GB2017/051385
International Filing Date 18.05.2017
IPC
C07J 71/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
71Steroids in which the cyclopentahydrophenanthrene skeleton is condensed with a heterocyclic ring
C07J 9/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
9Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
C07J 17/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
17Normal steroids containing carbon, hydrogen, halogen, or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopentahydrophenanthrene skeleton
C07J 33/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
33Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopentahydrophenanthrene skeleton
C07J 41/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
C07J 43/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
43Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopentahydrophenanthrene skeleton
CPC
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
C07J 13/007
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
13Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
007with double bond in position 17 (20)
C07J 17/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
17Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
C07J 21/006
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
21Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
005Ketals
006at position 3
C07J 21/008
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
21Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
005Ketals
008at position 17
C07J 31/006
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
31Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
006not covered by C07J31/003
Applicants
  • NZP UK LIMITED [GB]/[GB]
Inventors
  • WEYMOUTH-WILSON, Alexander Charles
  • KOMSTA, Zofia
  • WALLIS, Laura
  • EVANS, Timothy
  • DAVIES, Ieuan
  • OTTER, Carl
  • BATCHELOR, Rhys
Agents
  • O'KANE, Jessica
  • TEUTEN, Andrew
  • GOODALL, Scott
Priority Data
1608777.718.05.2016GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INTERMEDIATES FOR THE SYNTHESIS OF BILE ACID DERIVATIVES, IN PARTICULAR OF OBETICHOLIC ACID
(FR) INTERMÉDIAIRES POUR LA SYNTHÈSE DE DÉRIVÉS DE L'ACIDE BILIAIRE, EN PARTICULIER DE L'ACIDE OBÉTICHOLIQUE
Abstract
(EN)
The invention relates to compounds of general formula (I): wherein: R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease.
(FR)
La présente invention concerne des composés de formule (I), dans lesquels R1, R2, R3, R4, R5, R6 et Y sont tels que définis ici. Les composés sont des intermédiaires dans la synthèse des acides biliaires synthétiques qui sont utiles dans le traitement d'affections tels qu'une maladie du foie.
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