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1. (WO2017198989) IMPROVEMENTS IN AND RELATING TO SKIN SAMPLE VIABILITY

Pub. No.:    WO/2017/198989    International Application No.:    PCT/GB2017/000081
Publication Date: Fri Nov 24 00:59:59 CET 2017 International Filing Date: Tue May 23 01:59:59 CEST 2017
IPC: A01N 1/02
C12N 5/071
Applicants: THE UNIVERSITY OF DUNDEE
Inventors: HICKERSON, Robyn Patricia
CONNEELY, Michael John
Title: IMPROVEMENTS IN AND RELATING TO SKIN SAMPLE VIABILITY
Abstract:
A method for improving the ex vivo viability of a skin tissue type by mounting samples (27) of the skin tissue type in a skin sample holder (23), applying separate tensions to at least some of the samples and measuring the ability of at least some of the skin tissue samples to maintain live skin characteristics, such as to determine one or more value of skin tension which improve the ex vivo viability of the skin sample type. Tension may be measured using a force meter. The viability may be determined by wounding the skin, e.g. using a laser source, and measuring keratin 17 expression. Cellular viability and/or metabolic activity may also be determined.