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1. (WO2017198989) IMPROVEMENTS IN AND RELATING TO SKIN SAMPLE VIABILITY
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Pub. No.: WO/2017/198989 International Application No.: PCT/GB2017/000081
Publication Date: 23.11.2017 International Filing Date: 22.05.2017
IPC:
A01N 1/02 (2006.01) ,C12N 5/071 (2010.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
1
Preservation of bodies of humans or animals, or parts thereof
02
Preservation of living parts
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
Applicants:
THE UNIVERSITY OF DUNDEE [GB/GB]; 11 Perth Road Dundee, Scotland, GB
Inventors:
HICKERSON, Robyn Patricia; GB
CONNEELY, Michael John; GB
Agent:
BLACK, Simon John; Black and Associates Limited Office 2/1, 211 Dumbarton Road Glasgow G11 6AA, GB
Priority Data:
GB1608899.920.05.2016GB
Title (EN) IMPROVEMENTS IN AND RELATING TO SKIN SAMPLE VIABILITY
(FR) AMÉLIORATIONS APPORTÉES ET RELATIVES À LA VIABILITÉ D'ÉCHANTILLON DE PEAU
Abstract:
(EN) A method for improving the ex vivo viability of a skin tissue type by mounting samples (27) of the skin tissue type in a skin sample holder (23), applying separate tensions to at least some of the samples and measuring the ability of at least some of the skin tissue samples to maintain live skin characteristics, such as to determine one or more value of skin tension which improve the ex vivo viability of the skin sample type. Tension may be measured using a force meter. The viability may be determined by wounding the skin, e.g. using a laser source, and measuring keratin 17 expression. Cellular viability and/or metabolic activity may also be determined.
(FR) L'invention concerne un procédé pour améliorer la viabilité ex vivo d'un type de tissu de peau en montant des échantillons (27) du type de tissu de peau dans un support d'échantillon de peau (23), en appliquant des tensions distinctes sur au moins certains des échantillons, et en mesurant la capacité d'au moins certains des échantillons de tissu de peau à conserver des caractéristiques de peau vivante, de façon à déterminer une ou plusieurs valeurs de tension de peau qui améliorent la viabilité ex vivo du type d'échantillon de peau. Une tension peut être mesurée à l'aide d'un dispositif de mesure de force. La viabilité peut être déterminée en enroulant la peau, par exemple à l'aide d'une source laser, et en mesurant l'expression de kératine 17. La viabilité cellulaire et/ou l'activité métabolique peuvent également être déterminées.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)