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1. (WO2017198849) DERIVATIVES OF LIMONOIDS FOR TREATING AND/OR PREVENTING GROWTH OF BREAST CANCER CELLS

Pub. No.:    WO/2017/198849    International Application No.:    PCT/EP2017/062166
Publication Date: Fri Nov 24 00:59:59 CET 2017 International Filing Date: Sat May 20 01:59:59 CEST 2017
IPC: A61K 31/366
A61P 35/00
Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
UNIVERSITE DE NANTES
UNIVERSITE D'ANGERS
Inventors: BARILLE-NION, Sophie
TEA, Illa
DIOUM, Mbaye Diaw
Title: DERIVATIVES OF LIMONOIDS FOR TREATING AND/OR PREVENTING GROWTH OF BREAST CANCER CELLS
Abstract:
The present invention relates to new compounds derivatives of limonoids for treating and/or preventing growth of cancer cells, particularly for treating the breast cancer. Breast cancer is cancer that develops from breast tissue. It is the most common invasive cancer in women. The inventors have now discovered new derivatives of type limonoid, which possess a powerful anticancer activity, with, at the same time, low toxicity. They have demonstrated that these novel derivatives are efficient against breast cancer cell lines. In particular, the present invention relates to compounds of formula (I) for use for treating the breast cancer. Particularly, the inventors tested the compounds on cell line MDA-MB-468, and in particular, the impact of the compounds on mitotic phase and on cell death in cancer cells have been analysed.