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1. (WO2017198839) DESTABILISING DOMAINS FOR CONDITIONALLY STABILISING A PROTEIN
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/198839 International Application No.: PCT/EP2017/062150
Publication Date: 23.11.2017 International Filing Date: 19.05.2017
IPC:
C12N 9/06 (2006.01) ,C12N 15/52 (2006.01) ,C12N 15/62 (2006.01)
Applicants: VIHINEN, Mauno[FI/SE]; SE
KIRIK, Deniz[SE/SE]; SE
Inventors: VIHINEN, Mauno; SE
KIRIK, Deniz; SE
Agent: HØIBERG P/S; Adelgade 12 1304 Copenhagen K, DK
Priority Data:
1650693-320.05.2016SE
Title (EN) DESTABILISING DOMAINS FOR CONDITIONALLY STABILISING A PROTEIN
(FR) DOMAINES DE DÉSTABILISATION POUR LA STABILISATION CONDITIONNELLE D'UNE PROTÉINE
Abstract:
(EN) The present disclosure relates to mutant polypeptides derived from Escherichia coli dihydrofolate reductase (DHFR) which can be fused to a polypeptide of interest for efficient conditional modulation of its activity. Also disclosed are polynucleotides encoding such mutant polypeptides, vectors comprising such polynucleotides, and the5 use of such polypeptides, polynucleotides and vectors for treating a disorder.
(FR) La présente invention concerne des polypeptides mutés dérivés de la dihydrofolate réductase (DHFR) d'Escherichia coli qui peuvent être fusionnés à un polypeptide d'intérêt pour une modulation conditionnelle efficace de son activité. L'invention concerne également des polynucléotides codant ces polypeptides mutés, des vecteurs comprenant ces polynucléotides, et l'utilisation de ces polypeptides, polynucléotides et vecteurs pour traiter une affection.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)