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1. (WO2017198726) TRI-SEGMENTED PICHINDE VIRUSES AS VACCINE VECTORS
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Pub. No.: WO/2017/198726 International Application No.: PCT/EP2017/061865
Publication Date: 23.11.2017 International Filing Date: 17.05.2017
IPC:
C12N 15/86 (2006.01) ,C07K 14/005 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
03
Herpetoviridae, e.g. pseudorabies virus
05
Epstein-Barr virus
Applicants:
UNIVERSITÄT BASEL [CH/CH]; Vizerektorat Forschung Petersgraben 35 4001 Basel, CH
HOOKIPA BIOTECH GMBH [AT/AT]; AT
Inventors:
BONILLA, Weldi; CH
PINSCHEWER, Daniel David; CH
ORLINGER, Klaus; AT
Agent:
JONES DAY (ASSOCIATION NO. 215); Prinzregentenstraße 11 80538 München, DE
Priority Data:
62/338,40018.05.2016US
Title (EN) TRI-SEGMENTED PICHINDE VIRUSES AS VACCINE VECTORS
(FR) VIRUS PINCHIDE TRI-SEGMENTÉS UTILES EN TANT QUE VECTEURS VACCINAUX
Abstract:
(EN) The present application relates to Pichinde viruses with rearrangements of their open reading frames ("ORF") in their genomes. In particular, described herein is a modified Pichinde virus genomic segment, wherein the Pichinde virus genomic segment is engineered to carry a viral ORF in a position other than the wild-type position of the ORF. Also described herein are trisegmented Pichinde virus particles comprising one L segment and two S segments or two L segments and one S segment. The Pichinde virus, described herein may be suitable for vaccines and/or treatment of diseases and/or for the use in immunotherapies.
(FR) La présente invention concerne des virus Pinchide qui présentent des réarrangement de leurs cadres de lecture ouverts (ORF) ou de leurs génomes. En particulier, l'invention concerne un segment génomique de virus Pinchide modifié, ce segment génomique de virus Pinchide étant manipulé afin de porter un ORF viral dans une position autre que celle de la position de type sauvage de l'ORF. L'invention concerne également des particules de virus Pinchide trisegmenté comprenant un segment L et deux segments S ou deux segments L et un segment S. Le virus Pinchide décrit dans cette invention peut être approprié à des vaccins et/ou au traitement de maladies et/ou à une utilisation dans des immunothérapies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)