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1. (WO2017198617) METHOD FOR ASSESSING A PROGNOSIS AND PREDICTING THE RESPONSE OF PATIENTS WITH MALIGNANT DISEASES TO IMMUNOTHERAPY

Pub. No.:    WO/2017/198617    International Application No.:    PCT/EP2017/061612
Publication Date: Fri Nov 24 00:59:59 CET 2017 International Filing Date: Tue May 16 01:59:59 CEST 2017
IPC: C12Q 1/68
Applicants: DIETRICH, Dimo
Inventors: DIETRICH, Dimo
Title: METHOD FOR ASSESSING A PROGNOSIS AND PREDICTING THE RESPONSE OF PATIENTS WITH MALIGNANT DISEASES TO IMMUNOTHERAPY
Abstract:
The invention relates to, among others, a method for assessing a prognosis of a patient with a malignant disease and/or for predicting the response of a patient with a malignant disease to immunotherapy. For this purpose, a DNA methylation analysis is carried out on at least one immunoregulatory gene of cells of the malignant disease and/or T lymphocytes which interact with the cells of the malignant disease, said gene coding for an immune checkpoint selected from B7 proteins and the receptors thereof, MHC-peptide complex-binding co-receptors, the members of the tumor necrosis factor receptor superfamily TNFRSF9, CD40, TNFRSF4, TNFRSF18, and CD27, the members of the immunoglobulin superfamily TIGIT, BTLA, HAVCR2, BTNL2, and CD48, and the andenosine-binding adenosine 2A receptor.