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1. (WO2017198341) MACROCYCLIC INDOLE DERIVATIVES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/198341    International Application No.:    PCT/EP2017/000629
Publication Date: 23.11.2017 International Filing Date: 17.05.2017
IPC:
C07D 487/14 (2006.01), C07D 487/04 (2006.01), C07D 498/04 (2006.01), C07D 498/14 (2006.01), C07D 498/20 (2006.01), A61K 31/4162 (2006.01), A61P 35/00 (2006.01)
Applicants: BAYER AKTIENGESELLSCHAFT [DE/DE]; Kaiser-Wilhelm-Allee 1 51373 Leverkusen (DE).
BAYER PHARMA AKTIENGESELLSCHAFT [DE/DE]; Müllerstr. 178 13353 Berlin (DE).
THE BROAD INSTITUTE, INC. [US/US]; 415 Main St. Cambridge, MA 02142 (US)
Inventors: WAGNER, Sarah; (DE).
BUCHGRABER, Philipp; (DE).
KLAR, Ulrich; (DE).
CHRIST, Clara; (DE).
FERNANDEZ-MONTALVAN, Amaury, Ernesto; (DE).
MÖWES, Manfred; (DE).
LIENAU, Philipp; (DE).
EIS, Knut; (DE).
SACK, Ulrike; (DE).
MÖNNING, Ursula; (DE).
SCHOLZ, Arne; (DE).
KUHNKE, Joachim; (DE).
THEDE, Kai; (DE).
WERBECK, Nicolas; (DE).
SERRANO-WU, Michael; (US).
LEMKE, Chris; (US).
MCKINNEY, David; (US).
FITZGERALD, Mark; (US).
NASVESCHUK, Christopher; (US).
LAZARSKI, Kiel; (US).
FERRARA, Steven, James; (US).
FURST, Laura; (US).
WEI, Guo; (US).
MCCARREN, Patrick, Ryan; (US)
Agent: BIP PATENTS; c/o Bayer Intellectual Property GmbH Alfred-Nobel-Straße 10 40789 Monheim am Rhein (DE)
Priority Data:
62/338,942 19.05.2016 US
16172726.8 02.06.2016 EP
Title (EN) MACROCYCLIC INDOLE DERIVATIVES
(FR) DÉRIVÉS D'INDOLE MACROCYCLIQUES
Abstract: front page image
(EN)The present invention relates to macrocyclic indole derivatives of general formula (I) : (I), in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
(FR)La présente invention concerne des composés indole macrocycliques de formule générale (I) : (I) dans laquelle R1, R2, R3, R4, R5, R6, A et L sont tels que définis dans la description, des procédés de préparation desdits composés, des composés intermédiaires utiles pour préparer lesdits composés, des compositions et combinaisons pharmaceutiques comprenant lesdits composés, et l'utilisation desdits composés pour la fabrication de compositions pharmaceutiques pour le traitement ou la prophylaxie de maladies, en particulier de maladies hyperprolifératives et/ou inflammatoires, en monothérapie ou en association avec d'autres principes actifs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)