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1. WO2017198258 - METHOD FOR FORMING A FUNCTIONAL NETWORK OF HUMAN NEURONAL AND GLIAL CELLS

Publication Number WO/2017/198258
Publication Date 23.11.2017
International Application No. PCT/DE2017/100408
International Filing Date 12.05.2017
IPC
A61L 27/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
22Polypeptides or derivatives thereof
CPC
A61L 2300/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
60characterised by a special physical form
64Animal cells
A61L 2430/32
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
32for nerve reconstruction
A61L 27/227
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
14Macromolecular materials
22Polypeptides or derivatives thereof ; , e.g. degradation products
227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
A61L 27/26
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
14Macromolecular materials
26Mixtures of macromolecular compounds
A61L 27/383
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
38containing added animal cells
3804characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
383Nerve cells, e.g. dendritic cells, Schwann cells
A61L 27/3834
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
38containing added animal cells
3804characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
3834Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
Applicants
  • LEIBNIZ-INSTITUT FÜR POLYMERFORSCHUNG DRESDEN E. V. [DE]/[DE]
  • DEUTSCHES ZENTRUM FÜR NEURODEGENERATIVE ERKRANKUNGEN E. V. [DE]/[DE]
Inventors
  • PAPADIMITRIOU, Christos
  • KIZIL, Caghan
  • FREUDENBERG, Uwe
  • WERNER, Carsten
Agents
  • SPERLING, Thomas
Priority Data
10 2016 109 068.917.05.2016DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) VERFAHREN ZUR BILDUNG EINES FUNKTIONELLEN NETZWERKES VON HUMANEN NEURONALEN UND GLIALEN ZELLEN
(EN) METHOD FOR FORMING A FUNCTIONAL NETWORK OF HUMAN NEURONAL AND GLIAL CELLS
(FR) PROCÉDÉ POUR FORMER UN RÉSEAU FONCTIONNEL DE CELLULES NEURONALES ET GLIALES HUMAINES
Abstract
(DE)
Die Erfindung betrifft ein Verfahren zur Bildung eines funktionellen Netzwerkes von humanen neuronalen und glialen Zellen, bei dem die Zellen in ein synthetisches Hydrogelsystem mit den Komponenten Polyethylenglykol (PEG) und Heparin eingebracht und darin kultiviert werden, wobei das Einbringen der Zellen in das PEG-Heparin-Hydrogelsystem zusammen mit einer der Gelkomponenten, entweder PEG oder Heparin, erfolgt, mit der die Zellen zuvor vermischt wurden, so dass sich die Zellen während der Bildung des dreidimensionalen Hydrogels bereits im Hydrogelsystem befinden.
(EN)
The invention relates to a method for forming a functional network of human neuronal and glial cells, wherein the cells are introduced into a synthetic hydrogel system with the components polyethylene glycol (PEG) and heparin and are cultivated therein. The cells are introduced into the PEG heparin hydrogel system together with one of the gel components, either PEG or heparin, with which the cells were previously mixed such that the cells are already located in the hydrogel system during the formation of the three-dimensional hydrogel.
(FR)
La présente invention concerne un procédé pour former un réseau fonctionnel de cellules neuronales et gliales humaines, les cellules étant introduites dans un système d’hydrogel de synthèse comprenant les constituants polyéthylène glycol (PEG) et héparine, et y étant cultivées, l’introduction des cellules dans le système d’hydrogel PEG-héparine s’effectuant conjointement avec l’un des constituants du gel, soit PEG, soit héparine, constituant avec lequel les cellules ont été préalablement mélangées de sorte que les cellules se trouvent déjà dans le système d’hydrogel lors de la formation de l’hydrogel tridimensionnel.
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