Provided is an anti-theft lock system against technical unlocking, comprising a lock body (20) and a key (10). The key (10) comprises a key shank (12) with an inserted bar (11), and an unlocking part (13). The unlocking part (13) is a strip-like insert block with a sector-shaped cross section, an upper portion of the strip-like insert block is provided with a second unlocking bit (131), and a lower portion thereof is provided with a first unlocking bit (132). The lock body (20) comprises an outer lock case (21) and an integrated key cylinder. The cylindrical integrated key cylinder is disposed inside the outer lock case (21). The integrated key cylinder comprises an inner key cylinder (22) and an outer key cylinder (23), and the outer key cylinder (23) is nested outside the inner key cylinder (22). The inner and outer key cylinders (22, 23) can be rotated coaxially, a key insertion hole (221) and a first tumbler mechanism (222) are provided in the inner key cylinder (22), a rotating pin (223) is provided on the body of the inner key cylinder (22), a drive guide slot (231) and two rows of holes (232, 233) coupled with the inner key cylinder are provided on an inner wall of the outer key cylinder (23). The outer lock case (21) is provided with a projection (211), and a second tumbler mechanism (212) is disposed in the projection (211). A key insertion hole is provided on the top of the outer lock case (21), and the shape of the key insertion hole is formed by connecting and combining a columnar insertion hole (213) and an insertion hole (214) in the unlocking part with the sector-shaped cross section.