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1. (WO2017198124) MULTI-ARM POLYMERIC TARGETING ANTI-CANCER CONJUGATE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/198124    International Application No.:    PCT/CN2017/084328
Publication Date: 23.11.2017 International Filing Date: 15.05.2017
IPC:
A61K 31/4745 (2006.01), C08G 65/34 (2006.01), C08G 65/48 (2006.01), A61P 35/00 (2006.01)
Applicants: BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO., LTD. [CN/CN]; C27 Building Bio-Bay, No.218, Xinghu Street, Industrial Park SuZhou, Jiangsu 215123 (CN)
Inventors: YUAN, Jiandong; (CN).
HUANG, Yangqing; (CN).
SONG, Yunsong; (CN).
YUAN, Fang; (CN)
Agent: LINDA LIU & PARTNERS; F16 Tower C, Beijing Global Trade Center, 36 North Third Ring East Road, Dongcheng District Beijing 100013 (CN)
Priority Data:
201610318195.3 16.05.2016 CN
Title (EN) MULTI-ARM POLYMERIC TARGETING ANTI-CANCER CONJUGATE
(FR) CONJUGUÉ DE CIBLAGE POLYMÈRE À BRAS MULTIPLES ANTICANCÉREUX
(ZH) 多臂的聚合靶向抗癌偶联物
Abstract: front page image
(EN)Disclosed is a multi-arm targeting drug coupling agent modified by a water-soluble polymer; the drug coupling agent has the structural formula of (III). In formula (III), R is an organic center, POLY is a polymer, L is a polyvalent linker, T is a targeting molecule, D is a camptothecin drug, and q is any integer between 3 and 8. The drug conjugate can improve the poor water solubility, high toxicity and low bioavailability of camptothecin drugs.
(FR)L'invention porte sur un agent de couplage de médicament de ciblage à bras multiples modifié par un polymère soluble dans l'eau ; l'agent de couplage de médicament présentant la formule développée (III). Dans la formule (III), R représente un centre organique, POLY un polymère, L une séquence de liaison polyvalente, T une molécule de ciblage, D un médicament à base de camptothécine et q un nombre entier compris entre 3 et 8. Le conjugué médicamenteux peut améliorer la médiocre solubilité dans l'eau, la toxicité élevée et la faible biodisponibilité des médicaments à base de camptothécine.
(ZH)公开了一种多臂的、由水溶性聚合物修饰的靶向药物偶联剂,该药物偶联剂具有如(III)结构式。其中,R为有机中心,POLY为聚合物,L为多价接头,T为靶向分子,D为喜树碱类药物,q为3-8之间的任一整数。所述药物偶联物能够改善喜树碱类药物差的水溶性、高的毒性和低的生物利用率。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)