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1. (WO2017198124) MULTI-ARM POLYMERIC TARGETING ANTI-CANCER CONJUGATE

Pub. No.:    WO/2017/198124    International Application No.:    PCT/CN2017/084328
Publication Date: Fri Nov 24 00:59:59 CET 2017 International Filing Date: Tue May 16 01:59:59 CEST 2017
IPC: A61K 31/4745
C08G 65/34
C08G 65/48
A61P 35/00
Applicants: BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO., LTD.
博瑞生物医药(苏州)股份有限公司
Inventors: YUAN, Jiandong
袁建栋
HUANG, Yangqing
黄仰青
SONG, Yunsong
宋云松
YUAN, Fang
袁芳
Title: MULTI-ARM POLYMERIC TARGETING ANTI-CANCER CONJUGATE
Abstract:
Disclosed is a multi-arm targeting drug coupling agent modified by a water-soluble polymer; the drug coupling agent has the structural formula of (III). In formula (III), R is an organic center, POLY is a polymer, L is a polyvalent linker, T is a targeting molecule, D is a camptothecin drug, and q is any integer between 3 and 8. The drug conjugate can improve the poor water solubility, high toxicity and low bioavailability of camptothecin drugs.