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1. (WO2017197726) BONE-TARGETED GENE CARRIER, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Pub. No.:    WO/2017/197726    International Application No.:    PCT/CN2016/087283
Publication Date: Fri Nov 24 00:59:59 CET 2017 International Filing Date: Tue Jun 28 01:59:59 CEST 2016
IPC: C12N 15/88
A61K 48/00
A61K 9/127
Applicants: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY, CHINESE ACADEMY OF SCIENCES
中国科学院深圳先进技术研究院
Inventors: ZHAO, Xiaoli
赵晓丽
ZHENG, Chuping
郑楚萍
Title: BONE-TARGETED GENE CARRIER, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Abstract:
The present invention provides a bone-targeted gene carrier. The bone-targeted gene carrier is an alendronate sodium-modified liposome which comprises cationic lipid, neutral auxiliary lipid, cholesterol, and alendronate sodium-modified phospholipid. The cationic lipid, neutral auxiliary lipid, and cholesterol constitute a phospholipid layer. The alendronate sodium-modified phospholipid is interspersed in the phospholipid layer and forms a vesicle structure with the phospholipid layer. The alendronate sodium is exposed out of the phospholipid layer. The bone-targeted gene carrier has high targeting ability and transfection efficiency for bone tissues and can allow a loaded genetic material to be efficiently expressed near bone tissues. The present invention also provides a preparation method for the bone-targeted gene carrier and an application of the bone-targeted gene carrier.