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1. (WO2017197342) METHODS FOR TREATING LIVER TISSUE

Pub. No.:    WO/2017/197342    International Application No.:    PCT/US2017/032524
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Sat May 13 01:59:59 CEST 2017
IPC: A61K 9/00
A61K 31/135
A61K 45/00
A61K 45/06
A61P 35/00
A61P 43/00
Applicants: TECLISON LIMITED
LU, Daoling
Inventors: LEE, Ruey-min
Title: METHODS FOR TREATING LIVER TISSUE
Abstract:
Methods and kits are provided for administering a hypoxia-activated bioreductive agent by applying the agent locally to liver tissue when hepatic arterial pressure is reduced. Local arterial application when pressure is reduced tissue prolongs the duration of tissue exposure to the hypoxia-activated bioreductive agent. Hepatic pressure may be reduced proximal to the liver tissue. In some embodiments, local application may be followed by embolization when arterial pressure is reduced. Embolization under reduced pressure may decrease complications associated with backflow and increase the efficacy of the hypoxia-activated agent.