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1. (WO2017197335) NASAL EPITHELIUM GENE EXPRESSION SIGNATURE AND CLASSIFIER FOR THE PREDICTION OF LUNG CANCER

Pub. No.:    WO/2017/197335    International Application No.:    PCT/US2017/032517
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Sat May 13 01:59:59 CEST 2017
IPC: C12Q 1/68
G01N 33/53
G01N 33/574
Applicants: TRUSTEES OF BOSTON UNIVERSITY
Inventors: SPIRA, Avrum
LENBURG, Marc
PEREZ-ROGERS, Joseph
ANDERLIND, Christina
Title: NASAL EPITHELIUM GENE EXPRESSION SIGNATURE AND CLASSIFIER FOR THE PREDICTION OF LUNG CANCER
Abstract:
Disclosed herein are assays and methods for diagnosis and prognosis of lung cancer using expression analysis of one or more genes from a biological sample comprising nasal epithelial cells. The assays and methods of the invention provide non-invasive means of accurately detecting the presence or absence of lung cancer relative to, for example, more invasive techniques, such as bronchoscopy. Similarly, in certain aspects, the assays and methods disclosed herein provide non-invasive means of accurately identifying the smoking history of a subject.