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1. (WO2017197300) RECOVERING LONG-RANGE LINKAGE INFORMATION FROM PRESERVED SAMPLES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/197300 International Application No.: PCT/US2017/032466
Publication Date: 16.11.2017 International Filing Date: 12.05.2017
IPC:
C12N 15/10 (2006.01) ,C12N 15/11 (2006.01) ,C40B 40/06 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
10
Processes for the isolation, preparation or purification of DNA or RNA
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40
Libraries per se, e.g. arrays, mixtures
04
Libraries containing only organic compounds
06
Libraries containing nucleotides or polynucleotides, or derivatives thereof
Applicants: DOVETAIL GENOMICS LLC[US/US]; 2161 Delaware Ave. Santa Cruz, California 95060, US
Inventors: TROLL, Christopher John; US
POWERS, Martin P.; US
PUTNAM, Nicholas H.; US
BLANCHETTE, Marco; US
HARTLEY, Paul; US
Agent: ANDERSON, Garrett H.; US
Priority Data:
62/336,25213.05.2016US
62/410,59920.10.2016US
Title (EN) RECOVERING LONG-RANGE LINKAGE INFORMATION FROM PRESERVED SAMPLES
(FR) RÉCUPÉRATION D'INFORMATIONS DE LIAISON DE LONGUE PORTÉE À PARTIR D’ÉCHANTILLONS CONSERVÉS
Abstract:
(EN) The disclosure provides methods to isolate genome or chromosome level structural information from preserved samples. In some cases, samples preserved under conditions where long-range nucleic acid information is believed to be irreparably lost, such as FFPE samples, are treated to recover nucleic acid-protein complexes stabilized as part of the sample preservation process. The complexes are processed so as to recover information regarding which nucleic acids are bound to a common complex, and the information is used to recover genomic structural information.
(FR) La présente divulgation concerne des procédés permettant d'isoler des informations structurales au niveau du génome ou du chromosome à partir d'échantillons conservés. Dans certains cas, les échantillons conservés dans des conditions où les informations sur les acides nucléiques de longue portée sont réputées irrémédiablement perdues, telles que les échantillons FFPE, sont traités pour récupérer des complexes acide nucléique-protéine stabilisés lors du processus de conservation des échantillons. Les complexes sont traités de façon à récupérer les informations sur les acides nucléiques liés à un complexe commun, et ces informations sont utilisées pour récupérer des informations génomiques structurales.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)