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1. (WO2017197253) PEPTIDES AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS
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Pub. No.: WO/2017/197253 International Application No.: PCT/US2017/032387
Publication Date: 16.11.2017 International Filing Date: 12.05.2017
IPC:
A61K 38/17 (2006.01) ,A61K 39/395 (2006.01) ,A61P 25/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
OHIO STATE INNOVATION FOUNDATION [US/US]; 1524 North High Street Columbus, Ohio 43201, US
Inventors:
SHEN, Yingjie; US
GU, Yuanzheng; US
XU, Kui; US
Agent:
SMITH, Amanda; US
HALL, Miles E.; US
MEUNIER, Andrew T.; US
CARLIN, Gregory J.; US
CURFMAN, Christopher L.; US
Priority Data:
62/335,15912.05.2016US
Title (EN) PEPTIDES AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS
(FR) PEPTIDES ET MÉTHODES PERMETTANT DE TRAITER DES TROUBLES NEURODÉGÉNÉRATIFS
Abstract:
(EN) Disclosed herein are compositions and methods for treating and preventing neurodegenerative diseases, such as Alzheimer's disease. In some embodiments, the composition comprises a peptide that disrupts the binding between PTPσ and APP, preventing β-amyloidogenic processing of APP without affecting other major substrates of β- and ϒ-secretases. Alternatively, in some embodiments, an antibody or a fragment of an antibody against PTPσ or APP may be used to disrupt the binding between PTPσ and APP. In some embodiments, the composition comprises compounds or enzymes, which restore perineuronal balance of PTPσ ligands CS and HS, thereby preventing abnormally increased β-amyloidogenic processing of APP. Compositions and methods disclosed herein can be used in combination to treat and prevent neurodegenerative diseases.
(FR) L'invention concerne des compositions et des méthodes de traitement et de prévention de maladies neurodégénératives, telles que la maladie d'Alzheimer. Dans certains modes de réalisation, la composition comprend un peptide qui coupe la liaison entre la PTPσ et l'APP, empêchant le traitement β-amyloïdogénique de l'APP sans affecter d'autres substrats majeurs des β- et des ϒ-secrétases. En variante, dans certains modes de réalisation, un anticorps ou un fragment d'un anticorps dirigé contre la PTPσ ou l'APP peut être utilisé pour couper la liaison entre la PTPσ et l'APP. Dans certains modes de réalisation, la composition comprend des composés ou des enzymes, qui rétablissent l'équilibre péri-neuronal des ligands CS et HS de la PTPσ, ce qui permet d'empêcher un traitement β-amyloïdogénique anormalement accru de l'APP. Les compositions et les méthodes décrites dans la présente description peuvent être utilisées en association pour traiter et prévenir des maladies neurodégénératives.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)