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1. (WO2017197243) CBLB INHIBITION FOR TREATING FUNGAL INFECTIONS

Pub. No.:    WO/2017/197243    International Application No.:    PCT/US2017/032370
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Sat May 13 01:59:59 CEST 2017
IPC: C12N 15/11
A61K 48/00
A61K 38/00
C07H 21/04
Applicants: OHIO STATE INNOVATION FOUNDATION
Inventors: ZHANG, Jian
RAPPLEYE, Chad
Title: CBLB INHIBITION FOR TREATING FUNGAL INFECTIONS
Abstract:
Disclosed herein is a method for treating a fungal infection in a subject that involves administering to the subject a composition comprising a therapeutically effective amount of a casitas B lymphoma-b (CBLB) inhibitor. Specifically, wherein the CBLB inhibitor is an siRNA. Further disclosed are specific nucleic acid sequences of siRNA CBLB inhibitors.