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1. (WO2017197241) TARGETED CONSTRUCTS AND FORMULATIONS THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/197241    International Application No.:    PCT/US2017/032366
Publication Date: 16.11.2017 International Filing Date: 12.05.2017
IPC:
A61K 47/54 (2017.01), A61K 47/55 (2017.01), A61K 47/64 (2017.01), A61K 47/66 (2017.01)
Applicants: TARVEDA THERAPEUTICS, INC. [US/US]; 134 Coolidge Avenue Watertown, Massachusetts 02472 (US)
Inventors: WHITE, Brian H.; (US).
MOREAU, Benoît; (US).
BILODEAU, Mark T.; (US).
KADIYALA, Sudhakar; (US)
Agent: WARD, Donna T.; (US).
ZHU, Heng; (US)
Priority Data:
62/336,120 13.05.2016 US
62/476,123 24.03.2017 US
Title (EN) TARGETED CONSTRUCTS AND FORMULATIONS THEREOF
(FR) CONSTRUCTIONS CIBLÉES ET LEURS FORMULATIONS
Abstract: front page image
(EN)Targeted constructs and pharmaceutical formulations thereof, comprising at least one conjugate of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via an optional internal linker moiety have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the targeted constructs and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
(FR)L'invention concerne des constructions ciblées et leurs formulations, qui comprennent au moins un conjugué d'un ingrédient actif, tel qu'un agent thérapeutique, prophylactique ou de diagnostic fixé à une fraction de ciblage par l'intermédiaire d'un agent de liaison, et qui ont été créées pour assurer une livraison spatio-temporelle améliorée de l'ingrédient actif et/ou une meilleure biodistribution. L'invention concerne également des procédés de production desdites constructions ciblées et de leurs formulations. L'invention concerne également des méthodes d'administration des formulations à un sujet en ayant besoin, par exemple pour traiter ou prévenir le cancer ou les maladies infectieuses.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)